Diabetes can lead to Alzheimer’s disease, La Jolla researchers find
by HANNA LAUKKANEN
Published - 05/02/16 - 10:20 AM | 16080 views | 718 718 comments | 27 27 recommendations | email to a friend | print
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
slideshow
The workable human brain wasn’t created to last 70 to 90 years. That’s why our brains have different neurologic diseases when we age, like Parkinson's or Alzheimer's. Senior associate Karthik Bodhinathan and postdoctoral associate Mohammed Waseem Akhtar are researching new medical care for Alzheimer’s disease at La Jolla’s Sanford Burnham Prebys Medical Discovery Institute.

“There aren’t very good drugs out there,” Bodhinathan explains, “and even the ones that are out, they hit multiple targets, which mean they cure what you need but also create side effects, like depression and suicidal behavior. My job is to see if we can refine them.”

Akhtar is finding out more about the link between Alzheimer's and diabetes.

“Generally,” he says, “the people with diabetes have roughly two times higher the risk of developing Alzheimer's disease.”

There are several reasons for that, he says, but the main reason centers on the sugar level in diabetic patient. High levels affect neuronal function and causes dysfunction in the powerhouses of the brain.

“In the diabetic brain, you see that they decline in learning and memory, which is what you see in an Alzheimer’s brain,” Akhtar notes.

Bodhinathan is researching the chemicals that affect the brain in prior unknown ways. It’s a big challenge, he says, because most times the drugs don’t do what researchers predict. Researchers change the chemistry, fueling a lengthy retesting process.

“I’m trying to see if we can use the brain’s different mechanism to clear these toxic proteins in the brain,” Bodhinathan says. “They attract more proteins, and they become this big gob in the brain – and we believe that once we attack those clusters, we will be able to cure the disease.”

In a related development, the U.S. Food and Drug Administration has approved Acadia Pharmaceutical’s Nuplazid drug for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. In 2014 the FDA designated Nuplazid as a “breakthrough therapy” for this condition.

Acadia, based in San Diego, plans in June to make Nuplazid commercially available to patients suffering from hallucinations and delusions associated with Parkinson’s disease psychosis in the United States.

According to the National Parkinson Foundation, about 1 million people in the United States and from 4 to 6 million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, characterized by hallucinations and delusions. This is associated with significant caregiver burden and is a major reason for nursing home placement among Parkinson’s patients.

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mary suzan
|
12 Hours Ago
Hello everyone. Dr. Osalu Herbs is a good remedy for herpes Virus , I was a carrier of herpes virus and I saw a testimony on how Dr. Osalu cure Herpes Virus, I decided to contact him, I contacted him and he guided me. I asked him for solutions and he started the remedies for my health. After he finish he sent me the herbs which i took for 2 weeks before asking me to go for a check up and getting there i could not believe that i was confirm HSV 2 Negative after the test,Today i am so happy because i'm free from herpes disease with the help of Dr. Osalu Thank God now everything is fine, I'm cured by Dr. Osalu herbal medicine, I'm very thankful to God for making it possible. you can reach him on his email, i strongly recommend him to any one out here looking for a cure . drosaluherbalhome@gmail.com or call/whatsapp 2348078668950.
ruth fraser
|
April 20, 2019
THIS IS HOW I GOT CURED FROM HERPES VIRUS!!!

I was diagnosed of HERPES Virus in 2017 and I have tried

all I can to get cured but all to no avail, until i saw a post in a health

forum about a herbalist man who prepare herbal medication to cure all kind

of diseases including HERPES virus, at first i doubted if it was real but

decided to give it a try, when i contact this herbalist via his email and

he prepared a HERPES herbal cure and sent it to me via fed-ex delivery

company service, when i received this herbal cure, he gave me step by

directions on how to apply it, when i applied it as instructed, i was

totally cured of this deadly disease within 10

days of usage, I am now free from the deadly disease called herpes, all

thanks to Dr Osalu. Contact this great herbal doctor via his email:

(drosaluherbalhome@gmail.com ) or whats app

him on 2348078668950.

Dr. Osalu cure all kinds of sickness or diseases such as:

1. HERPES VIRUS

2. LASSA FEVER

3. GONORRHEA

4. HIV/AIDS

5. LOW SPERM COUNT

6. MENOPAUSE DISEASE

7. EPILEPSY

9. CANCER

10.KIDNEY PROBLEM

11. PREGNANCY PROBLEM

12.SHORTSIGHTEDNESS PROBLEM

13.MENSTRUATION PROBLEM.

14. MISS-CARRIAGE.

ETC.
natatia wilson
|
April 20, 2019
HOW I GOT CURED FROM GENITAL HERPES COMPLECTED.

I know there is no cure for genital herpes but take a moment and read my testimony.

My health was horrible before I decided to try the Protocol Of taking Dr HENRY herbal mixture. I felt there was no hope for my health and I was doubtful to try the Protocol thinking it wouldn’t work because I have visited so many hospital but same result. However, I was convinced by my friend to try the herbal medicine because I wanted to get rid of herpes. The herbal mixture that was given to me was really quick and easy to take, and since I have be taking it for less than 3 days I have less outbreak. But within one week i was fully cured from herpes simple. We herbal medicine really work and I will like to share this great herb doctor contact with you all email him henryazakaherbalhome@gmail.com or whatsapp 2348107397241. Pls try and help yourself out of herpes completely today. ACCORDING TO HIM HE ALSO CURE ALL TYPE OF ILLNESS LIKE

DIABETES

ALL TYPE HERPES

HIV

FIBROID

HPV....
SUSIE KARI
|
April 20, 2019
I believed God has sent Dr Alli to help people out from this horrible virus. i was diagnosis with genital herpes for 3 years, few months ago a friend introduced me to Dr Alli, and i only took his natural treatment for 2 weeks & 3 days, i got cured permanently with his herbal treatment. Dr Alli email is Allispellhelp1@gmail.com or whats App 2348100772528
SUSIE KARI
|
April 20, 2019
I believed God has sent Dr Alli to help people out from this horrible virus. i was diagnosis with genital herpes for 3 years, few months ago a friend introduced me to Dr Alli, and i only took his natural treatment for 2 weeks & 3 days, i got cured permanently with his herbal treatment. Dr Alli email is Allispellhelp1@gmail.com or whats App 2348100772528

Rose Alex
|
April 20, 2019
Happiness is all i see now I never thought that I will be cured from HERPES virus again. I have been suffering from a deadly disease (HERPES) for the past 3 years now, I had spent a lot of money going from one places to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I was searching through the internet, I saw a testimony on how DR unity helped someone in curing his HERPES disease, quickly I copied his email which is drunityspellhome789@gmail.com just to give him a test I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days after using the herbal cure, behold I was free from the deadly disease, he only asked me to post the testimony through the whole world, faithfully am doing it now, please brothers and sisters, he is great, I owe him in return. if you are having a similar problem just email him on his email drunityspellhome789@gmail.com or Whats app number 2349055346802

Dr UNITY CAN AS WELL CURE THE FOLLOWING DISEASE:-

1. HERPES

2. LASSA FEVER

3. GONORRHEA

4. HIV/AIDS

5. LOW SPERM COUNT

6. MENOPAUSE DISEASE

7. EPILEPSY

8. ASEPSIS

9. CANCER

10. ANXIETY DEPRESSION

11. PREGNANCY PROBLEM

12. ALS

13. HPV

14. ENLARGEMENT OF ANY TYPE

15. GETTING YOUR EX LOVER BACK

16.HEPATITIS,A,B,C

17. SYPHILIS

18.. ARTHRITIS

19. SEVERE ATOPIC DERMATITIS
SUSIE KARI
|
April 19, 2019
I believed God has sent Dr Alli to help people out from this horrible virus. i was diagnosis with genital herpes for 3 years, few months ago a friend introduced me to Dr Alli, and i only took his natural treatment for 2 weeks & 3 days, i got cured permanently with his herbal treatment. Dr Alli email is Allispellhelp1@gmail.com or whats App 2348100772528

SUSIE KARI
|
April 19, 2019
I believed God has sent Dr Alli to help people out from this horrible virus. i was diagnosis with genital herpes for 3 years, few months ago a friend introduced me to Dr Alli, and i only took his natural treatment for 2 weeks & 3 days, i got cured permanently with his herbal treatment. Dr Alli email is Allispellhelp1@gmail.com or whats App 2348100772528

Catherine Minor
|
April 19, 2019
Am here to appreciate Dr. Okasi for using his herbal medicine to cure my Herpes virus I was diagnosed of herpes 3 years ago I have been living with this virus and it has been giving me challenges, I was so perplexed cause i have been taking several drugs to be cured but all of my effort was in vain,one morning i was browsing through the internet then i saw several testimonies about Dr. Okasi curing people from Herpes virus and immediately i contacted Dr. Okasi on his Email: okasiherbalsolution@outlook.com, i told him about my troubles and he told me that i must be cured, he gave me some instructions and which i rightly followed, so he prepared a herbal medicine for me and sent it to me which i used for 2 weeks and everything was like a dream to me and my Herpes virus was totally gone, why don't you contact him today and be free from your diseases because he is very good and honest Doctor. contact him via Email:okasiherbalsolution@outlook.com.

mary care
|
April 19, 2019
I was depressed when doctor told me that I have been diagnosed with Herpes disease… I thought about my Family, I know my Family will face a serious problem when I'm gone, I lost hope and I wept all day, but one day I was searching the internet I found Dr.ezomo contact number. 2349069171173 I called him and he guided me. I asked him for solutions and he started the remedies for my health. Thank God, now everything is fine, I'm cured by Dr.ezomo herbal medicine, I'm very thankful to Dr.ezomo and very happy with my hubby and family. email him on dr.ezomorootandherbals@gmail.com or you can also reach him through WhatsApp number 2349069171173 He can also cure so many sickness {1}HIV And AIDS {2}Diabetes {3}Epilepsy {4}Blood Cancer {5}HPV {7}ALS {8}Hepatitis
Catherine Minor
|
April 19, 2019
Am here to appreciate Dr. Okasi for using his herbal medicine to cure my Herpes virus I was diagnosed of herpes 3 years ago I have been living with this virus and it has been giving me challenges, I was so perplexed cause i have been taking several drugs to be cured but all of my effort was in vain,one morning i was browsing through the internet then i saw several testimonies about Dr. Okasi curing people from Herpes virus and immediately i contacted Dr. Okasi on his Email: okasiherbalsolution@outlook.com, i told him about my troubles and he told me that i must be cured, he gave me some instructions and which i rightly followed, so he prepared a herbal medicine for me and sent it to me which i used for 2 weeks and everything was like a dream to me and my Herpes virus was totally gone, why don't you contact him today and be free from your diseases because he is very good and honest Doctor. contact him via Email:okasiherbalsolution@outlook.com..

karen kennedy
|
April 19, 2019
I'm here to testify about the great work Dr Aza did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr Aza on how he cured her from Herpes Simplex Virus. And she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him on drazaherbalcenter@gmail.com telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr Aza assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact Dr Aza via email drazaherbalcenter@gmail.com. You can also call or whatsApp his telephone number on 1(315) 795 1518 . Thanks once again Dr Aza.
joel lisa
|
April 19, 2019
Am Lisa by name, i was diagnosed with Herpes for 3years ago i lived in pain with the knowledge that i wasn't going to ever be well again i contacted so many herbal doctors on this issue and wasted a large sum of money but my condition never got better i was determined to get my life back so one day i saw mr Brown post on how Dr Aba saved him from the VIRUS with herbal medicine i contacted Dr Aba on his email address dr.abaherbalhome@gmail.com we spoke on the issue i told him all that i went through and he told me not to worry that everything will be fine again so he prepared the medicine and send it to me through courier service and told me how to use it,after 14days of usage I went to see the doctor for test ,then the result was negative,am the happiest woman on earth now. this testimony is real.thanks to Dr Aba God bless you. you can also reach him on his whatsApp number 2348107155060
Brooke May
|
April 18, 2019


My herpes is cured and it's miracle healing. Thanks to Dr. Sam who cure my Genital Herpes

I was in trouble when doctor told me that I have been diagnosed with Genital Herpes. I thought about my Family, how they will feel if they knew, i was also felling pains in my Anus and vagina. I lost hope and I wept all day, but one day I was surfing the internet I found about Dr. Sam on how he cured a lady with natural herbs, I decided to contact him through his mobile number, i also wrote him letter through his email address. he guided me. I asked him for solutions and he prepared a herbal remedy and send to me,when i received it, i started taking it as directed. Thank God, now everything is fine, I’m cured by Dr. Sam herbal medicine, I’m very thankful to God and very happy with my and very happy with my hubby and family. You can contact him through his email address on Email: supremecurehome@gmail.com Or WhatsApp/Call number 2347087462033
David Anna
|
April 18, 2019
Here i am today to tell the world how Dr Ajayi cured me from herpes i have be having herpes since two years,i have work with other herbal doctor,but noon of this herbs work,not until one day i came across the testimony of a lady that way also having herpes and got cured by Dr Ajayi . then i contacted his email and told him about my problems, he told me not to worry that i am in the right place.i didn't believe him when he said so,he told me what to do for him to cure me and i did,so a month after he have send me the herbal medicine i went for checkup and find out that am cured i was so happy to hear that,so i went back and tell Dr Ajayi that the medicine work and am cured.are you out there having same problem here is the key to be cure.. contact him via email ajayiherbalhome@gmail.com,you can also call whatsapp his mobile number 2348154724883 he also have cure to other sickness like:

HIV/AIDS

HEPATITIS

CANCER

HERPES

TYPHOID

COLD SCORES
Elizabeth Matheus
|
April 16, 2019
HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..

2017 MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR OLIHA ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR OLIHA VIA HIS EMAIL; OLIHA.MIRACLEMEDICINE@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON 2349038382931 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON 2349038382931.ALL THANKS TO DOCTOR DR OLIHA
Elizabeth Matheus
|
April 16, 2019
HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..

2017 MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR OLIHA ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR OLIHA VIA HIS EMAIL; OLIHA.MIRACLEMEDICINE@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON 2349038382931 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON 2349038382931.ALL THANKS TO DOCTOR DR OLIHA
sarah rita
|
April 16, 2019
herpes is a serious and recurring disease which can't be cured through drugs or injections by the American doctors but the best way to deal with herpes is by taking natural herbs medicine for it and is only few American doctors that know about this herbal medicine from Dr Obudu.. I have read about Dr Obudu the great herbalist doctor from African who can cure disease with his powerful herbal medicine. for the people suffering from the following diseases, Herpes, Cancer, Also,Herpatitis, Diabetes, Hps,Infections ETC should contact him for his herbal medicine because i am a living testimony and i was cured of herpes. Although, i sent him what he requested and he sent me his medicine which i took for 1 weeks and today when i went for test i was tested herpes negative. you can reach him through his email drobuduherbalhome@gmail.com or whatsapp number: 2349023428871 he will help you out
ERWIN ERIN
|
April 16, 2019
Hello Everyone, my names is Erwin Erin, i m from Florida USA. I want to share my testimonies to the general public on how this great man called Dr Maggi cure my herpes. I have been a HERPES patient for over 7 Months and i have been in pains until i came across this lady when i traveled to Africa for Business trip who happen to once been a herpes patient, i explained every thing to her and she told me that there is this Great Dr that help her to cure her herpes and she gave me his email address for me to contact and i did as she instructed. And the man Dr Maggi told me how much to buy the herpes herbal medication and how i will get it, which i did. And to my greatest surprise that i took the Herpes herbal medicine for just one week and behold i went for a herpes test, for to my greatest surprise for the Doctor confirmed me to herpes free and said that i no longer have herpes in my system and till now i have never felt any pains nor herpes again, so i said i must testify the goodness of this man to the general public for if you are there surfing from this Herpes problems or any deadly disease or other disease for i will advice you to contact him on his working email: Maggiherbalcenter@gmail.com and i assure you that he will help you just as he did for me okay contact him on his email: Maggiherbalcenter@gmail.com THESE ARE THE THINGS DR MAGGI DOES 1. HERPES 2. LASSA FEVER 3. GONORRHEA 4. HIV/AIDS 5. LOW SPERM COUNT 6. MENOPAUSE DISEASE 7. EPILEPSY 8. ASEPSIS 9. CANCER 10. ANXIETY DEPRESSION 11. PREGNANCY PROBLEM 12. SHORT SIGHTEDNESS PROBLEM 14. Male menopause 15. Menopause - male 16. Menopause - peri 17. Menstruation problems 18. Mercury Poisoning 19. Migraine 20. Miscarriage 21. Mites (demode x mites) 22. Mites (scabies mites) 23. Motion sickness 24. Mouth ulcer 25. MRSA 26. Multiple sclerosis 27. Muscle cramps 28. Myodesopsia 29. Stroke 30. He can as well cast and remove spell or whatsapp him on 1[306]993-9253 or text 1(662)967-1783.and you can also visit him on his webs:maggiherbalcenter.wixsite.com/drmaggi.
nakul mahanda
|
April 16, 2019


Hello everyone I want to thank Dr wonders for saving my marriage life I was having serious issue with my penis because I was not satisfying my wife on bed which was causing problem in my relationship until I found Dr wonders email address Dr.wonderspellhome@yahoo.com on Facebook of someone he helped I decided to give him a try to my surprise Dr wonders prepare a herbal enlargement cream and sent to me which I used as I was instructed to do dear friends you won't believe that my small penis which was causing problem to my marriage life was bigger than before when I started to apply the herbal enlargement cream am very happy now that my penis is bigger and I can now satisfy my wife on bed she is always happy with me all thank to Dr wonders you can mail dr.wonderspellhome@yahoo.com or Whatsapp 2348141269531 for help..

Mike Dana
|
April 18, 2019
I can’t believe my genital herpes is really cured, oh is by this time last year I start feeling bad about my life, I feel pain everyday of my life am very happy now that am really cured I couldnt have do this on my own I wish is not God that help me with my helper I was searching the internet about this sickness last 3month when I found about great doctor itama, the man that keep his words I write the man email about my problem immediately I get a reply from him asking me to fill a form which I immediately did and send back to him after some mins he reply me that he have work on my cure that I need to provide some materials, which can enable him to work on my cure which I did on the next day of it, after some hours he inform me that he have getting the things needed for the cure and he is about to go on with the curing spell he called me again after 50mins that he is done with the cure that I should check my body and also go for test I cant believe I was negative, a big thanks to him am very happy now with my family you can also get your self cured too from this sickness by contact him through his email dr.itamacuringhome@gmail.com you call or whatsapp him number 2348165485326
ose joy
|
April 15, 2019
God bless Dr AIKHOMU for his marvelous work in my life, I was diagnosed of HERPES SIMPLEX VIRUS since 2017 and I was taking my medications, I wasn't satisfied i needed to get the HERPES out of my system, I searched about some possible cure for HERPES i saw a comment about Dr AIKHOMU, how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine within 3 days. I took the medicine as prescribed by him and 2 weeks later i was cured from HERPES contact him via email once again thanks to you Dr AIKHOMU. cure the flowing virus, contact his email draikhomuherbalhome@gmail.com or add him on whatsapp 2348100962873 or my number whatsapp 1(442)270-9712

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