Diabetes can lead to Alzheimer’s disease, La Jolla researchers find
Published - 05/02/16 - 10:20 AM | 187 187 comments | 24 24 recommendations | email to a friend | print
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
The workable human brain wasn’t created to last 70 to 90 years. That’s why our brains have different neurologic diseases when we age, like Parkinson's or Alzheimer's. Senior associate Karthik Bodhinathan and postdoctoral associate Mohammed Waseem Akhtar are researching new medical care for Alzheimer’s disease at La Jolla’s Sanford Burnham Prebys Medical Discovery Institute.

“There aren’t very good drugs out there,” Bodhinathan explains, “and even the ones that are out, they hit multiple targets, which mean they cure what you need but also create side effects, like depression and suicidal behavior. My job is to see if we can refine them.”

Akhtar is finding out more about the link between Alzheimer's and diabetes.

“Generally,” he says, “the people with diabetes have roughly two times higher the risk of developing Alzheimer's disease.”

There are several reasons for that, he says, but the main reason centers on the sugar level in diabetic patient. High levels affect neuronal function and causes dysfunction in the powerhouses of the brain.

“In the diabetic brain, you see that they decline in learning and memory, which is what you see in an Alzheimer’s brain,” Akhtar notes.

Bodhinathan is researching the chemicals that affect the brain in prior unknown ways. It’s a big challenge, he says, because most times the drugs don’t do what researchers predict. Researchers change the chemistry, fueling a lengthy retesting process.

“I’m trying to see if we can use the brain’s different mechanism to clear these toxic proteins in the brain,” Bodhinathan says. “They attract more proteins, and they become this big gob in the brain – and we believe that once we attack those clusters, we will be able to cure the disease.”

In a related development, the U.S. Food and Drug Administration has approved Acadia Pharmaceutical’s Nuplazid drug for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. In 2014 the FDA designated Nuplazid as a “breakthrough therapy” for this condition.

Acadia, based in San Diego, plans in June to make Nuplazid commercially available to patients suffering from hallucinations and delusions associated with Parkinson’s disease psychosis in the United States.

According to the National Parkinson Foundation, about 1 million people in the United States and from 4 to 6 million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, characterized by hallucinations and delusions. This is associated with significant caregiver burden and is a major reason for nursing home placement among Parkinson’s patients.

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19 Hours Ago
I am very happy today to share this amazing testimony on how Dr MAGGI the herbal doctor that was able to cure me from my Herpes Virus with his herbal medicine. I have been a Herpes patient for almost 8 months now and have tried different methods of treatment to ensure that I am cured of this terrible disease, but none worked for me, so I had to leave everything to God to handle as I was a Christian who had faith that one day God would intervene in my life, yet I felt so sad and desperate as I was losing almost everything due to my illness, A few months ago while I was searching the internet I saw different recommendation about Dr MAGGI on how he have been using his herbal Medicine to treat and cure people, these people advice we contact Dr MAGGI for any problem that would help immediately, I contacted Dr MAGGI and I told him how I got his contact and also about my disease, after some time Dr MAGGI told me to have faith that he would prepare for me a medication of herbal herbs, he told me I would take this medicine for a few weeks and also asked my home for home address so as possible for him to submit the medicine for me, so my good friends after all the process and everything Dr MAGGI actually sent me the medicine, I took it as I was directed by Dr MAGGI, after a few weeks passed, while on Dr MAGGI medication I began to experience changes in my body, I had to call my doctor at the hospital for some blood test after test my hospital doctor told me that I was no longer with the Herpes virus and my blood is pretty good, I can not even believe this, Friends well today i am Herpes Free and i want everyone to know that there is a cure for Herpes for those who will contact Dr MAGGI after reading my testimony, you can kindly contact Dr MAGGI on his email:Maggiherbalcenter@gmail.com or call his telephone number 1310-740-9300 or whatsaap him through his mobile} 2348148487280. You can also email me on pittamchelsie@gmail.com. I may not reply your mail immediately but at my leisure i will do so, Thanks once again DR. MAGGI.YOU ARE TRULY A GREAT HERBALIST.
celina jolly
21 Hours Ago
I was cured of HIV with the used of natural herbs. My name is celina jolly and am from US. I love herbs so much. Most times, injection and drugs are just a waste of time. I was cured 8 months ago, i suffered from HIV for 13 yrs but with the help of Dr.Ogun herbal medicine, i was cured within few weeks of drinking the herbs he sent to me through courier delivery service. This same doctor also cured my Aunty from herpes, as soon as i heard she had herpes, i quickly refer her to Dr.Ogun and she was cured too after drinking his herbs.I have referred more than 15 persons to Dr.Ogun and they were all cured from their various illness. Have you taken herbs before?. You have spent so much money on drugs,injections,surgeries etc and yet you have no good result to show for it. Contact Dr. Ogun now, he is a herbalist doctor, i assured you of a cure if you drink his natural herbs. Dr.Ogun have herbs that cures Hiv, Herpes, diabetics, asthma, hepatitis, HBP, STD, cancer, chronic, etc. Contact Dr ogun through his Email address on: drogun62@gmail.com or WHATSAPP/CALL him on 2348104991149 . Please share the good news to other people once you are cured
harry benson
November 24, 2017
Am Harry Benson, Dr Erediawa Okoh cure me of HSV-2 after i have lost my son. i was diagnosed with the herpes type 2 after doing Colposcopy. It was extremely painful I got them around the inner part of my bum. i visited different hospital but they gave me list of drugs like acyclovir, Zovirax, and (Valacyclovir )Valtrex which is very expensive to suppress symptom outbreak. It was more complicated when it was affecting my skin.I desperately look for solution browsing through the Internet searching for remedy on HSV-2 and i saw comment of people talking about how Dr Erediawa cured them from different virus like, HIV< HPV>HSV. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of HERPES. so i decided to contact him on his email that was listed on the comments drerediawaherbs@gmail.com or call him with 2348159412586) i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, the sores are gone HERPES result came out negative Contact, Dr Erediawa now on is Email:drerediawaherbs@gmail.com and Or call him with 2348159412586, to get all your problem solved and get your ex back. i wish every body can contact Dr Erediawa Okoh, to get all life problem solve.Sickness of any kind Like Stroke,help to cure Hepatitis B HIV /AIDS CANCER,BIPOLAR,DIABETES,HERPES,WARTS,ACNE,PREGNANCY,To Lose at Least 21 IBS of BELLY FAT ,Drug Addict and Masturbation,Bareness/infertility,Genital warts and Asthma Contact him today on drerediawaherbs@gmail.com or call 2348159412586
lynasia vernesa
November 23, 2017
DOCTOR MAGGI. YOU ARE GOD SENT TO HELP PEOPLE LIFE, I PRAY YOU WILL NOT DIE BEFORE YOUR TIME This is real take it serious, who will believe that a herb can cure herpes, i never believe that this will work, i have spend a lot getting drugs from the hospital to keep me healthy, it got to a time that i was waiting for is death to come because i was broke, one day i hard about this great man called Dr MAGGI who is well know for Herpes, HIV, and Cancer cure, i decided to email him I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared a herbal medicine (CURE) and sent it through Online Courier Service for delivery, he gave my details to the Courier Office. they told me that 3-5 days I will receive the package and after receiving it, i took the medicine as prescribed by him at the end of the one week, he told me to go to the hospital for a check up, and i went, surprisingly after the test the doctor confirm me Herpes simplex virus negative, i thought it was a joke, i went to other hospital and was also negative, thank you for saving my life, I promise I will always testify of your good works. if you are herpes simplex virus patient, OR you are be helping by someone before i will like to advice you to give this man a try and see what will happen to your life don't worry about the money you have be use contact him and I am sure you will get cured, contact him via: Email: Maggiherbalcenter@gmail.com 0R call/whatsapp his number on 2348148487280 THESE ARE THE THINGS DR MAGGI DOES. HIV, CANCER, ASTHMA, IMPOTENCE, LOW SPERM COUNT, BARENESS/INFERTILITY, I can’t stop talking about this man called Dr MAGGI cause he is a God sent to cure humans from different DISEASES with herbal medications, he cured me of GENITAL HERPES, he will also help you. Contact him today and you will have a testimony…Good luck!
November 23, 2017
Hello every one. I'm from US-Dallas. I'm am so excited am a Complete woman Again, I Was Infected With Herpes virus since 3 Years now I am devastated and am finding it hard to cope i was emotionally down I Have Been Seriously Praying To God And Searching For Cure.So as I was browsing through the Internet one day, I came across a website that suggested that Dr.HOPE can help cure any type of virus like Herpes, Hiv/Aids cancer and Asthma…e.t.c And I Contacted Him, He Sent Me A Medicine And Directed Me On How I Will Take The Medicine For 21 Days, I Did So And Went For A Test And My Result Came Out As Negative. I Am So Happy, I Shared Tears Of Happiness And I Have Taken It Upon My Self To Always Testify About How God Used Dr.HOPE To Solve My Problem. I Am A Clean woman Now, Without Any Virus If You Are Infected With Any Disease Like HIV AIDS, CANCER ,HERPES Or Any Other Disease You Can Also Be Happy Like Me,contact him now via Email:dr.hopesolutionhome@hotmail.com or call him on 2348139560075
November 22, 2017
Am here to testify of the miraculous work of a great traditional doctor called DR.ZUKU ..I have been suffering from Herpes since last 2 years with my Husband but today I am happy that am cure from it with the herbal medicine made by Dr.ZUKU the great healer, I was browsing the internet searching for help when I came across a testimony shared by someone on how Dr.ZUKU cure her from Herpes Disease. I quickly contacted him to get the cure and today i am now free from the Virus, I am so much happy today that we have someone like this great healer out there, so' people out there kindly contact this great doctor on his email address please sir keep your good work cause there are people out there who is in need of your healing medicine .once more contact him now drzukuspelltemple@gmail.com call or text 16177296273 Dr.Zuku can prepare Herbal medicine for all kind of disease. HIV. CANCER. HEPATITIS B.DIABETES.COLD SORES. Syphilis. HBV, HPV, STD's And many more.contact Dr.Zuku to get your healing.
November 22, 2017
contact peterwiseherbalcenter@gmail.com

he just helped me get rid of herpes simplex virus !

I've been trying for months to get a cure to my herpes but couldn't get any. i have cried every week about this and i searched and searched for a possible cure and who would help me but i got scammed by a lot of them, i felt like i couldn't live

then i came across a testimony of one Mrs grace who was cured of ALS BY this wonderful and understanding herbal healer

peter wise and immediately i contacted him and explain my condition to him he sent me his powerful herpes simplex virus herbs which i took and in less than a month all my body got healed , i couldn't believe it, now am free of herpes,totally free no more pains and my mouth , my genital area are so fresh and clear now ,

thank you so much peter wise! call or WHATSAPP him now at 2349059610643

if you have ANY problem and need it solved

rhonda brain
November 21, 2017


" I want to give almighty praise to DR Hope who cure me from herpes. He is a great man who God send from heaven to save people’s life, when i contacted this deadly virus disease i thought that was the end of the world for me little did I know that there is a man called DR Hope who has made a breakthrough in the cure of herpes with the help of herbal treatment which I confided in a friend in south Africa he told me about this man called DR Hope and how he cured the mum and dad from genital herpes after many years of living with this deadly diseases he told me of the cost and procedure I felt it worth a try after I have been spending so much on medical drugs to make me live like every normal human being so I contacted DR Hope and did as he commanded without missing his words he did all he needed to do and sent me the herbal medication via DHL shipment I took it as he directed it was exactly 19 days as DR Hope has spoken when he emailed me and told me to go for a check up again and I went to my greatest surprise it was negative I felt it was a dream so I went to three different hospital and it was still negative then I cried out in a loud voice and people gathered in the hospital and I told them my story in tears how this man called DR Hope have saved my life and they started demanding for his mail to contact him it was only last week my friend monica who was herpes positive came back from visiting DR Hope as a healthy woman I told her about DR Hope you can reach him through his email address dr.hopesolutionhome@hotmail.com. he never fails hold done my friend don't cry no more when our helper is here I believe in him he am sure you will be lucky as I am too just email him on dr.hopesolutionhome@hotmail.com he is a savior of life. any DISEASE: you have will be cure by DR Hope




4. ALS

5. Hepatitis B

6. Diabetes

7 Genital herpes

8 if anyone want to get how Menstruation back again

email: dr.hopesolutionhome@hotmail.com or call 2348139560075
November 21, 2017

I am here to give my testimony about Dr Hope who helped me.. i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by Dr Hope, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Dr Hope cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took for just 2 weeks and it seriously worked for me, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that there is no cure for herpes that is Not true just contact him and get cure from Dr Hope healing cure of all kinds of sickness you may have. Remember delay in treatment leads to death.. email: dr.hopesolutionhome@hotmail.com or call him on 2348139560075
luciana brandy
November 21, 2017
Hello everyone, I want to testify of how i got cured from Hepatitis B with the help of a great Dr eveoko I got diagnosed of Hepatitis B in 2013 I have visited several hospitals but all to no avail, my world was gradually coming to an end until i saw a post in a health forum about a herbal cure who casts herbal spells to cure all kind of deadly diseases including Hepatitis , ALS, MND, Epilepsy, Leukemia, Asthma, Cancer, Herpes,HIV/AIDS, at first i doubted if it was real but decided to give it a try, when i contact this herbal Dr. eveoko via his email:eveokoherbalhaome@outlook.com , and explain my problem to him and he told me that he is going to prepare a herbal spell portion and sent it to me, when i received this herbal spell portion, he gave me step by step instructions on how to use it, when i applied it as instructed, so i went for check up and i was cured of this deadly disease within a week, I am now free from Hepatitis B. All thanks to Dr.eveoko . Contact this great herbal cure via his email eveokoherbalhome@outlook.com or whats app him on 2348022010422 for more info lucianabrandy0@gmail.com
howard vivian
November 20, 2017
I'm here to testify about what DR. MAGGI did for me. I have been suffering from (GENITAL HERPES VIRUS) disease for the past 3 years and had constant pain and inching, especially in my private part. During the first year, I had faith in God that i would be cured someday.This disease started circulating all over my body and I have been taking treatment from my doctor, few weeks ago I came across a testimony of Rose Smith on the internet testifying about a Man called DR. MAGGI on how he cured her from 7 years HSV 2. And she also gave the email address of this man, advise anybody to contact him for help on any kind of diseases that he would be of help, so I emailed him telling him about my (HSV 2) he told me not to worry that I was going to be cured!! Well, I never doubted him I have faith he can cure me too,, DR. MAGGI prepared and sent me Healing Oil, Soap, roots and herbs which I took. In the first one week, I started experiencing changes all over me, after four weeks of using his Roots/ Herbs, Oil and Soap, I was totally cured. no more inching , pain on me anymore as DR. MAGGI assured me. After some time I went to my doctor to do another test behold the result came out negative. So friends my advise is if you have such disease or know anyone who suffers from it or any other disease like HPV, HBV, HIV, ALS, HBP, CANCER etc. you can contact DR. MAGGI for help via email} Maggiherbalcenter@gmail.com call 2347057375409 or whatsaap him through his mobile} 2348148487280. You can also email me on howardvivian222@gmail.com. I may not reply your mail immediately but at my leisure i will do so, Thanks once again DR. MAGGI for making me a happy woman again.
Marian Talley
November 20, 2017
This is real take it serious, who will believe that a herbal can cure six years HIV in my body, i never believe that this will work i have spend a lot when getting drugs from the hospital to keep me healthy, what i was waiting for is death because i was broke, one day i hard about this great man who is well know of HIV and cancer cure, i decided to email him, unknowingly to me that this will be the end of the HIV aids in my body, he prepare the herb for me, and give me instruction on how to take it, at the end of the two week, he told me to go to the hospital for a check up, and i went, surprisingly after the test the doctor confirm me negative, i thought it was a joke, i went to other hospital was also negative, then i took my friend who was also HIV positive to the Dr, after the treatment she was also confirm negative . He also have the herb to cure cancer please i want every one with this virus to be free, that is why am dropping his email address, dr.atakumaoracle@outlook.com and his contact 2347064693371 dr.atakumaoracle@outlook.com do email him he is a great man. the government is also interested in this DR, thank you for saving my life, and I promise I will always testify for your good work add him now on whatsapp 2347064693371
November 20, 2017
May God continue to bless Dr Koba for his awesome work he is doing to save many lives, i have been a sufferer of HSV 1&2 disease which i didn't know how i got it, but when i found out about it 5years ago i have been very angry and stress getting a remedy, and doctors say there is no cure for HSV 1&2 disease, but one wonderful morning i was out searching out for herbal remedy and i saw a comment of someone talking about how Dr Koba has cured them and i to the next page someone else was also talking about Dr Koba, i was relieve and happy that finally i have found someone that has remedy for me, i contacted his Email address:drkobaherbalsolutionhome@gmail.com and before i knew it he replied me and that how i got my herbal medicine and i used it for only 2weeks i was totally cured, i am so happy viewers contact Dr Koba and get your cure now, or what app him: 2349037387574 or contact his website:drkobaherbalsolutionhome.wordpress.com
Judith Brayn
November 18, 2017
My name is Judith Brayn!!I was married for seven years without any child, because of this my husband start acting strange, coming home lately and not spending time with me any more and he divorced me. So i became very sad and lost in life because my doctor told me there is no way for me to get pregnant this really make life miserable for me. until i came across a friend who told me about Baba Alika from the Internet, how he has helped a lot of women with this similar problems that i am going through so i contacted him on: (babaalikahealinghome@gmail.com) and explained to him. he told me all what to provide before he could cast a reunite spell to bring back my husband which i did and he sent a powerful prayer which i had to say at mid night while he cast the love spell. It was a miracle, 72 hours later my one and only husband came back to me and apologize for all he has done and told me he is fully ready to support me in any thing i want,i quickly call Baba Alika and told him what was going on at that moment and he also prepared and sent me a herbal medicine which he said it will cure every unwanted infections or diseases that has been stopping me from conceiving then instructed me on how to use it before meeting with my husband behold after using this native herbs and root, few weeks later i started feeling pregnancy signs all over me, truly i was pregnant i just gave birth to twins (boys) on the 1st of this month. I Vow to let the whole world know about Baba Alika for saving my relationship and for also giving me children i can proudly call my own today. For any woman who think it impossible, here is an opportunity for you to smile and bring happiness to your family kindly contact Baba Alika via Email on: (babaalikahealinghome@gmail.com). Indeed, he is a God sent to bring back lost lovers and bring you happiness....