Diabetes can lead to Alzheimer’s disease, La Jolla researchers find
by HANNA LAUKKANEN
Published - 05/02/16 - 10:20 AM | 12036 views | 291 291 comments | 27 27 recommendations | email to a friend | print
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
slideshow
The workable human brain wasn’t created to last 70 to 90 years. That’s why our brains have different neurologic diseases when we age, like Parkinson's or Alzheimer's. Senior associate Karthik Bodhinathan and postdoctoral associate Mohammed Waseem Akhtar are researching new medical care for Alzheimer’s disease at La Jolla’s Sanford Burnham Prebys Medical Discovery Institute.

“There aren’t very good drugs out there,” Bodhinathan explains, “and even the ones that are out, they hit multiple targets, which mean they cure what you need but also create side effects, like depression and suicidal behavior. My job is to see if we can refine them.”

Akhtar is finding out more about the link between Alzheimer's and diabetes.

“Generally,” he says, “the people with diabetes have roughly two times higher the risk of developing Alzheimer's disease.”

There are several reasons for that, he says, but the main reason centers on the sugar level in diabetic patient. High levels affect neuronal function and causes dysfunction in the powerhouses of the brain.

“In the diabetic brain, you see that they decline in learning and memory, which is what you see in an Alzheimer’s brain,” Akhtar notes.

Bodhinathan is researching the chemicals that affect the brain in prior unknown ways. It’s a big challenge, he says, because most times the drugs don’t do what researchers predict. Researchers change the chemistry, fueling a lengthy retesting process.

“I’m trying to see if we can use the brain’s different mechanism to clear these toxic proteins in the brain,” Bodhinathan says. “They attract more proteins, and they become this big gob in the brain – and we believe that once we attack those clusters, we will be able to cure the disease.”

In a related development, the U.S. Food and Drug Administration has approved Acadia Pharmaceutical’s Nuplazid drug for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. In 2014 the FDA designated Nuplazid as a “breakthrough therapy” for this condition.

Acadia, based in San Diego, plans in June to make Nuplazid commercially available to patients suffering from hallucinations and delusions associated with Parkinson’s disease psychosis in the United States.

According to the National Parkinson Foundation, about 1 million people in the United States and from 4 to 6 million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, characterized by hallucinations and delusions. This is associated with significant caregiver burden and is a major reason for nursing home placement among Parkinson’s patients.

Comments
(291)
Comments-icon Post a Comment
Marykat
|
3 Hours Ago
Natural herbs have cured so many illness that drugs and injection cant cure. I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. i read people's testimonies online on how they were cured of herpes, hiv, diabetics etc by Dr. Ogba Kosu herbal medicine, so i decided to contact the doctor because i know nature has the power to heal anything. I was diagnosed with hiv for the past 7 years but Dr. Ogba Kuso cured me with his herbs and i referred my aunt and her husband to him immediately because they were both suffering from herpes and they were cured too .I know is hard to believe but am a living testimony. There is no harm trying herbs. He is also a spell caster, he cast spells to restore broken marriages and a good luck spells to prosper and excel in life. Contact Dr. Ogba Kosu on: drogbakosu@gmail.com

Phone/Whatsap no: 2348137291215

facebook.com/Dr.OgbaKosucurecenter/
jessica ana
|
October 13, 2018
Am here to appreciate Dr Aba for using his herbal medicine to cure my Herpes virus. since 3 years now I have been living with this virus and it has been giving me challenges, I was so perplexed cause i have been taking several drugs to be cured but all of my effort was in vain,one morning i was browsing through the internet then i saw several testimonies about Dr. Aba curing people from Herpes virus and immediately i contacted Dr. Aba on his email: dr.abaherbalhome@gmail.com, i told him about my troubles and he told me that i must be cured, gave me some instructions and which i rightly followed. so he prepared a herbal medicine for me and sent it to me which i used for 2 weeks and everything was like a dream to me and my Herpes virus was totally gone, why don't you contact him today and be free from your diseases because he is very good and honest Doctor. contact him via email; dr.abaherbalhome@gmail.com or whatsApp him on 2348107155060
Laura Morris
|
October 12, 2018
I'm here to testify about the great work Dr Oniha did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr Oniha on how he cured her from Herpes Simplex Virus. And she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr Oniha assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact Dr Oniha via email onihaherbalhome@gmail.com. You can also call or whatsApp his telephone number 1 628 204 8530. Thanks once again Dr Oniha.

Nancy Joe
|
October 13, 2018
Greetings to the general public, Am Nancy Joe, i want to inform the public on how i was cured of HERPES Simplex Virus by a Doctor called DR.AGUDOMU i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how DR.AGUDOMU cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. I pray for you DR.AGUDOMU God will give you everlasting life, you shall not die before your time for being a sincere and great man. Am so happy, you can also contact him if you have any problem Email:DR.AGUDOMUHEALERTEMPLE@GMAIL.COM you can contact me for more information email me on nanacyjoe@gmail.com
Kelvin Amada
|
October 13, 2018
I might sound weird, awkward and nasty to most people but only the few ones will have a listen ear to what I am telling the world..... I contacted HERPES VIRUS since 2014 but I was recently cured from my HERPES VIRUS middle of last year JUNE 8th 2017 by dr ofure. I met with Doctor Ofure himself online when I read a post comment of someone testyfing on how she was cured from her HERPES VIRUS by this same doctor ofure. I collected the herbal doctor's contact number from the testifyer and I contacted the herbal doctor, I told him everything and how I have been suffering from HERPES VIRUS since 2014.... He told me I shouldn't be worried, that he is going to prepare an herbal medicine cure for me which he actually did and sent to me through UPS delivery service company. I got the medicine and I started using the medicine as I was told by the doctor and I followed the prescription and the dosage,,, after 14days of which I was told to use the herbal medicine, he asked me to go to the hospital for check up..... In fact my God in Heaven can bear me witness on this, behold! I was detected HERPES VIRUS FREE and ever since that day I have been going to several test and my result is always HERPES VIRUS FREE. I was cured from my HERPES VIRUS by doctor Ofure, I was so happy and I vowed to keep on sharing my own testimony to the entire public and world to know that HERPES VIRUS has a cure with the help of Professor Doctor Ofure herbal medicine you can get rid/cure of your HERPES VIRUS. He is such a powerful and great African herbal doctor.... I love him so much and may God continue to bless him and flourish his good works. His contact number is: 2348162868851, you can also add him up on whatsap with the same number, his facebook username is DR OFURE HERBAL HOME, you can send him a friend request/message him on facebook with the username (DR OFURE HERBAL HOME) Or you can send him a message to his email address: drofureherbalhome@gmail.com. God bless! you all.
Laura Morris
|
October 12, 2018
I'm here to testify about the great work Dr Oniha did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr Oniha on how he cured her from Herpes Simplex Virus. And she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr Oniha assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact Dr Oniha via email onihaherbalhome@gmail.com. You can also call or whatsApp his telephone number 1 628 204 8530. Thanks once again Dr Oniha.
Nancy Joe
|
October 11, 2018
Greetings to the general public, Am Nancy Joe, i want to inform the public on how i was cured of HERPES Simplex Virus by a Doctor called DR.AGUDOMU i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how DR.AGUDOMU cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. I pray for you DR.AGUDOMU God will give you everlasting life, you shall not die before your time for being a sincere and great man. Am so happy, you can also contact him if you have any problem Email:DR.AGUDOMUHEALERTEMPLE@GMAIL.COM you can contact me for more information email me on nanacyjoe@gmail.com
Nancy Joe
|
October 11, 2018
Greetings to the general public, Am Nancy Joe, i want to inform the public on how i was cured of HERPES Simplex Virus by a Doctor called DR.AGUDOMU i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how DR.AGUDOMU cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, my HERPES result came out negative. I pray for you DR.AGUDOMU God will give you everlasting life, you shall not die before your time for being a sincere and great man. Am so happy, you can also contact him if you have any problem Email:DR.AGUDOMUHEALERTEMPLE@GMAIL.COM you can contact me for more information email me on nanacyjoe@gmail.com
jessica ana
|
October 11, 2018
Am here to appreciate Dr Aba for using his herbal medicine to cure my Herpes virus. since 3 years now I have been living with this virus and it has been giving me challenges, I was so perplexed cause i have been taking several drugs to be cured but all of my effort was in vain,one morning i was browsing through the internet then i saw several testimonies about Dr. Aba curing people from Herpes virus and immediately i contacted Dr. Aba on his email: dr.abaherbalhome@gmail.com, i told him about my troubles and he told me that i must be cured, gave me some instructions and which i rightly followed. so he prepared a herbal medicine for me and sent it to me which i used for 2 weeks and everything was like a dream to me and my Herpes virus was totally gone, why don't you contact him today and be free from your diseases because he is very good and honest Doctor. contact him via email; dr.abaherbalhome@gmail.com or whatsApp him on 2348107155060
judith jones
|
October 10, 2018
HOW I GOT CURED FROM HERPES VIRUS .

I was diagnosed of HERPES virus and i have tried all I can to get cured but all to no avail,,until I saw a post in a health forum about a herbalist man who prepare herbal medications to cure all kind of diseases including HERPES virus,at first I doubted if it was real but decided to give it a try,when I contacted this herbalist via his email and he prepared a HERPES herbal cure and sent it to me via UPS delivery service, when I received this herbal medicine, he gave me step by direction on how to apply it,after applying the way I was instructed,I was totally cured of this deadly disease called HERPES, all thanks to Dr AZA ..Email this great herbal doctor via his email ( drazaherbalcenter@gmail.com) or Call him on 1(315) 795 1518 HE CAN ALSO CURE SICKNESS LIKE

{1}HIV/AIDS

{2}DIABETES

{3}EPILEPSY

{4} BLOOD CANCER

{5} HPV

{6} ALS

{7} HEPATITIS

{8}LOVE SPELL

{9} SICKLE AND ANAEMIA

[ drazaherbalcenter@gmail.com ]
justice jessica
|
October 09, 2018
I want to use this medium to let everybody know that HIV/AIDS has cure and that Dr Maggi herbs is the solution in curing hiv and herpes. Am Justice Jessica from United state(Los Angeles) i tested HIV/AIDS positive March 2016 then early this month i read article about Dr Maggi having the cure for Hiv,Herpes and so many other diseases,i decided to contact him through his email and phone number that was present on the comment and he explain to me about the cure and how he prepared it and everything that he needed and i play along too and after he finished preparing it, he send it to me through UPS and he gave me instructions on how to be using it and after i finish it i should go to hospital for checkup which i was able to finish the medicine within one week and 3 days and i called Dr Maggi to inform him i have finish the medication and he told me i should go to the hospital to checked my status which i actually did and i was tested HIV NEGATIVE i told everybody right there at the hospital how i got the cure and they were all surprise and joined me to celebrate and i called Dr Maggi and thank him for his good work and he told me to go and give thanks to God almighty that he alone has the ultimate power. If you have HIV, HERPES, CANCER of all kind, DIABETICS and any other diseases you can contact Dr Maggi for the cure and he will gladly send it to you. Dr Maggi email is Maggiherbalcenter@gmail.com or call 1(662) 967-1783 you can also WhatsApp him on 1(312) 767-3460 . His website is drmaggiherbalcenter.webs.com.,.,
justice jessica
|
October 09, 2018
I want to use this medium to let everybody know that HIV/AIDS has cure and that Dr Maggi herbs is the solution in curing hiv and herpes. Am Justice Jessica from United state(Los Angeles) i tested HIV/AIDS positive March 2016 then early this month i read article about Dr Maggi having the cure for Hiv,Herpes and so many other diseases,i decided to contact him through his email and phone number that was present on the comment and he explain to me about the cure and how he prepared it and everything that he needed and i play along too and after he finished preparing it, he send it to me through UPS and he gave me instructions on how to be using it and after i finish it i should go to hospital for checkup which i was able to finish the medicine within one week and 3 days and i called Dr Maggi to inform him i have finish the medication and he told me i should go to the hospital to checked my status which i actually did and i was tested HIV NEGATIVE i told everybody right there at the hospital how i got the cure and they were all surprise and joined me to celebrate and i called Dr Maggi and thank him for his good work and he told me to go and give thanks to God almighty that he alone has the ultimate power. If you have HIV, HERPES, CANCER of all kind, DIABETICS and any other diseases you can contact Dr Maggi for the cure and he will gladly send it to you. Dr Maggi email is Maggiherbalcenter@gmail.com or call 1(662) 967-1783 you can also WhatsApp him on 1(312) 767-3460 . His website is drmaggiherbalcenter.webs.com,
justice jessica
|
October 09, 2018
I want to use this medium to let everybody know that HIV/AIDS has cure and that Dr Maggi herbs is the solution in curing hiv and herpes. Am Justice Jessica from United state(Los Angeles) i tested HIV/AIDS positive March 2016 then early this month i read article about Dr Maggi having the cure for Hiv,Herpes and so many other diseases,i decided to contact him through his email and phone number that was present on the comment and he explain to me about the cure and how he prepared it and everything that he needed and i play along too and after he finished preparing it, he send it to me through UPS and he gave me instructions on how to be using it and after i finish it i should go to hospital for checkup which i was able to finish the medicine within one week and 3 days and i called Dr Maggi to inform him i have finish the medication and he told me i should go to the hospital to checked my status which i actually did and i was tested HIV NEGATIVE i told everybody right there at the hospital how i got the cure and they were all surprise and joined me to celebrate and i called Dr Maggi and thank him for his good work and he told me to go and give thanks to God almighty that he alone has the ultimate power. If you have HIV, HERPES, CANCER of all kind, DIABETICS and any other diseases you can contact Dr Maggi for the cure and he will gladly send it to you. Dr Maggi email is Maggiherbalcenter@gmail.com or call 1(662) 967-1783 you can also WhatsApp him on 1(312) 767-3460 . His website is drmaggiherbalcenter.webs.com
james cassandra
|
October 08, 2018
I was diagnosed of Herpes in 2015 and I have tried all possible means to get the cure but all to no avail, until i saw a post in a health forum about a Herbal Doctor(Dr Osalu) who prepares herbal medicine to cure all kind of diseases including Herpes, at first i doubted if it was real but decided to give it a try, when i contacted Dr Osalu through his Email: drosaluherbalhome@gmail.com he guided me and prepared a herbal medicine and sent it to me via courier Delivery service,when i received the package (herbal medicine) He gave me instructions on how to consume it,i started using it as instructed and i stooped getting outbreaks and the sores started vanishing, could you believe i was cured of this deadly virus within 10-14 days of using this REMEDY,couldn't believe the healing at first until i went for a check-up,indeed i was tested negative to HERPES.Contact this great herbal Doctor today via Email: drosaluherbalhome@gmail.com and get cured permanently. add him on whatsapp 2348078668950.
Robert Jennifer
|
October 08, 2018
I have be living with Oral herpes for over 4 years now and it has be a big problem to me. One day i came across a woman testimony on forum saying she get cured of her Herpes with the help of Dr Oniha herbal medicine at first i did not believe i was doubting because my doctor told me they is no cure for this disease,so i contact him with the email the lady drop and write to him about my problems the he told me not to worry that am in the right place he told me what to do to get cured so i really did it few month later i went to the doctor and do a test and discover that am totally cured of my Oral herpes then i wrote to him and thank him for curing me please are you out there I advice you to contact the great doctor know as Dr Oniha i promise to always share what you did for me conact him via email onihaherbalhome@gmail.com You can also call Or whatsAPP him on 1 (669)221-3962.
WILSON JOE
|
October 08, 2018
I'm is Wilson Joe i am from Texas,USA.It's been a while since I've written

to thank you for my life Doctor Olatunboson who helped me in my life. I

was infected with HERPES SIMPLEX VIRUS in early 2018, i went to many

hospitals for cure but there was no solution, so I was thinking how can I

get a solution out so that my body can be okay. One day my Aunt Bella

introduce me to Doctor Olatunboson having seen so many testimony online

about his herbal medication to cure HERPES and gave me his

email:drolatunboson@gmail.com , so i mail him. He told me all the things I

need to do and also give me instructions to follow, which I followed

properly. Before I knew what is happening after one weeks the HERPES that

was in my body got vanished. so if you are you are having herpes or any

kind of disease listed below

*HIV

*DIABETES

*CANCER

*STROKE

*INFERTILITY

*HEART DISEASE

and you also want cure, you can also email him at:

drolatunboson@gmail.com

Whatsapp Namber: 2348137221266

judith jones
|
October 07, 2018
HOW I GOT CURED FROM HERPES VIRUS .

I was diagnosed of HERPES virus and i have tried all I can to get cured but all to no avail,,until I saw a post in a health forum about a herbalist man who prepare herbal medications to cure all kind of diseases including HERPES virus,at first I doubted if it was real but decided to give it a try,when I contacted this herbalist via his email and he prepared a HERPES herbal cure and sent it to me via UPS delivery service, when I received this herbal medicine, he gave me step by direction on how to apply it,after applying the way I was instructed,I was totally cured of this deadly disease called HERPES, all thanks to Dr AZA ..Email this great herbal doctor via his email ( drazaherbalcenter@gmail.com) or Call him on 1(315) 795 1518 HE CAN ALSO CURE SICKNESS LIKE

{1}HIV/AIDS

{2}DIABETES

{3}EPILEPSY

{4} BLOOD CANCER

{5} HPV

{6} ALS

{7} HEPATITIS

{8}LOVE SPELL

{9} SICKLE AND ANAEMIA

[ drazaherbalcenter@gmail.com ]
lara joys
|
October 06, 2018


I was in trouble when my doctor told me that i have been diagnosed with

herpes and i know my family will face a serious problem . when i am gone i

lost hope and wept most of the time, but one day i was surfing the internet

i saw Dr. omohan herbal home contact number online i called him and he

guided me. i asked him for solutions and he started the remedy for my

health thank God,now everything is fine i am cured by Dr. omohan herbal

medicine am very thankful to Dr. omohan and very happy with my hobby and

family email him on (dromohanherbalmedicine@gmail.com) call/whatsapp number 2348164816038

He can as well cure the following disease;

Herpes,

Asthma,

Cancer,

HSV1, &

HSV2,

Hepatitis B,

HIV/AID ETC.

Comments are back! Simply post the comment (it'll complain about you failing the human test) then simply click on the captcha and then click "Post Comment" again. Comments are also welcome on our Facebook page.
Trending