Diabetes can lead to Alzheimer’s disease, La Jolla researchers find
by HANNA LAUKKANEN
Published - 05/02/16 - 10:20 AM | 9920 views | 194 194 comments | 24 24 recommendations | email to a friend | print
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
slideshow
The workable human brain wasn’t created to last 70 to 90 years. That’s why our brains have different neurologic diseases when we age, like Parkinson's or Alzheimer's. Senior associate Karthik Bodhinathan and postdoctoral associate Mohammed Waseem Akhtar are researching new medical care for Alzheimer’s disease at La Jolla’s Sanford Burnham Prebys Medical Discovery Institute.

“There aren’t very good drugs out there,” Bodhinathan explains, “and even the ones that are out, they hit multiple targets, which mean they cure what you need but also create side effects, like depression and suicidal behavior. My job is to see if we can refine them.”

Akhtar is finding out more about the link between Alzheimer's and diabetes.

“Generally,” he says, “the people with diabetes have roughly two times higher the risk of developing Alzheimer's disease.”

There are several reasons for that, he says, but the main reason centers on the sugar level in diabetic patient. High levels affect neuronal function and causes dysfunction in the powerhouses of the brain.

“In the diabetic brain, you see that they decline in learning and memory, which is what you see in an Alzheimer’s brain,” Akhtar notes.

Bodhinathan is researching the chemicals that affect the brain in prior unknown ways. It’s a big challenge, he says, because most times the drugs don’t do what researchers predict. Researchers change the chemistry, fueling a lengthy retesting process.

“I’m trying to see if we can use the brain’s different mechanism to clear these toxic proteins in the brain,” Bodhinathan says. “They attract more proteins, and they become this big gob in the brain – and we believe that once we attack those clusters, we will be able to cure the disease.”

In a related development, the U.S. Food and Drug Administration has approved Acadia Pharmaceutical’s Nuplazid drug for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. In 2014 the FDA designated Nuplazid as a “breakthrough therapy” for this condition.

Acadia, based in San Diego, plans in June to make Nuplazid commercially available to patients suffering from hallucinations and delusions associated with Parkinson’s disease psychosis in the United States.

According to the National Parkinson Foundation, about 1 million people in the United States and from 4 to 6 million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, characterized by hallucinations and delusions. This is associated with significant caregiver burden and is a major reason for nursing home placement among Parkinson’s patients.

Comments
(194)
Comments-icon Post a Comment
Maryjane12
|
April 09, 2018
Natural herbs have cured so many illness that drugs and injection cant cure. I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. i read people's testimonies online on how they were cured of herpes, hiv, diabetics etc by Dr. Ogba Kosu herbal medicine, so i decided to contact the doctor because i know nature has the power to heal anything. I was diagnosed with hiv for the past 7 years but Dr. Ogba Kuso cured me with his herbs and i referred my aunt and her husband to him immediately because they were both suffering from herpes but to God be the glory, they were cured too .I know is hard to believe but am a living testimony. There is no harm trying herbs. He is also a spell caster, he cast spell to restore broken marriages and he cast good luck spells to prosper and excel in life. Contact Dr. Ogba Kosu on: drogbakosu@gmail.com

Phone/Whatsap no: 2348137291215

facebook.com/Dr.OgbaKosucurecenter/
susan loveth
|
April 05, 2018
Hello everybody,

I don't just know the reason why some people is finding it difficult to believe that there is a cure for herpes, I have been suffering from herpes since last three years with my boyfriend but today I am happy that am cure from it with the herbal medicine of Dr Aba the great healer,I was browsing the internet searching for help when I came across a testimony shared by someone on how Dr Aba cure his herpes I was so much in need of getting his treatment but after all Dr Aba brought a smile to my face with his herbal medicine. I am so much happy today that we have someone like this great healer out there, so my people out there kindly contact this great healer on his email address: dr.abaherbalhome@gmail.com please sir keep your good work cause there are people out there who is in need of your healing medicine.once more contact him now: dr.abaherbalhome@gmail.com you can call him or whatsApp his number 2348107155060
TREVOR CONNELL
|
March 27, 2018
Have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr MAGGI and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr MAGGI telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email: Maggiherbalcenter@gmail.com or call/whatsapp him 2348148487280. He told me that he also help people to cure HIV VIRUS and also help people to bring their ex lover back. contact Dr.MAGGI if you have any problem. email: Maggiherbalcenter@gmail.com.
TREVOR CONNELL
|
March 27, 2018
Have been suffering from (HERPES SIMPLEX VIRUS) disease for the past four years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man Dr MAGGI and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr MAGGI telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email: Maggiherbalcenter@gmail.com or call/whatsapp him 2348148487280. He told me that he also help people to cure HIV VIRUS and also help people to bring their ex lover back. contact Dr.MAGGI if you have any problem. email: Maggiherbalcenter@gmail.com.
harry benson
|
November 24, 2017
Am Harry Benson, Dr Erediawa Okoh cure me of HSV-2 after i have lost my son. i was diagnosed with the herpes type 2 after doing Colposcopy. It was extremely painful I got them around the inner part of my bum. i visited different hospital but they gave me list of drugs like acyclovir, Zovirax, and (Valacyclovir )Valtrex which is very expensive to suppress symptom outbreak. It was more complicated when it was affecting my skin.I desperately look for solution browsing through the Internet searching for remedy on HSV-2 and i saw comment of people talking about how Dr Erediawa cured them from different virus like, HIV< HPV>HSV. I Was scared because i never believed in the Internet but i was convince to give him a try because i was having no hope of been cured of HERPES. so i decided to contact him on his email that was listed on the comments drerediawaherbs@gmail.com or call him with 2348159412586) i searched his email on net and i saw a lot of people testifying about his goodness. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, the sores are gone HERPES result came out negative Contact, Dr Erediawa now on is Email:drerediawaherbs@gmail.com and Or call him with 2348159412586, to get all your problem solved and get your ex back. i wish every body can contact Dr Erediawa Okoh, to get all life problem solve.Sickness of any kind Like Stroke,help to cure Hepatitis B HIV /AIDS CANCER,BIPOLAR,DIABETES,HERPES,WARTS,ACNE,PREGNANCY,To Lose at Least 21 IBS of BELLY FAT ,Drug Addict and Masturbation,Bareness/infertility,Genital warts and Asthma Contact him today on drerediawaherbs@gmail.com or call 2348159412586
lynasia vernesa
|
November 23, 2017
DOCTOR MAGGI. YOU ARE GOD SENT TO HELP PEOPLE LIFE, I PRAY YOU WILL NOT DIE BEFORE YOUR TIME This is real take it serious, who will believe that a herb can cure herpes, i never believe that this will work, i have spend a lot getting drugs from the hospital to keep me healthy, it got to a time that i was waiting for is death to come because i was broke, one day i hard about this great man called Dr MAGGI who is well know for Herpes, HIV, and Cancer cure, i decided to email him I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared a herbal medicine (CURE) and sent it through Online Courier Service for delivery, he gave my details to the Courier Office. they told me that 3-5 days I will receive the package and after receiving it, i took the medicine as prescribed by him at the end of the one week, he told me to go to the hospital for a check up, and i went, surprisingly after the test the doctor confirm me Herpes simplex virus negative, i thought it was a joke, i went to other hospital and was also negative, thank you for saving my life, I promise I will always testify of your good works. if you are herpes simplex virus patient, OR you are be helping by someone before i will like to advice you to give this man a try and see what will happen to your life don't worry about the money you have be use contact him and I am sure you will get cured, contact him via: Email: Maggiherbalcenter@gmail.com 0R call/whatsapp his number on 2348148487280 THESE ARE THE THINGS DR MAGGI DOES. HIV, CANCER, ASTHMA, IMPOTENCE, LOW SPERM COUNT, BARENESS/INFERTILITY, I can’t stop talking about this man called Dr MAGGI cause he is a God sent to cure humans from different DISEASES with herbal medications, he cured me of GENITAL HERPES, he will also help you. Contact him today and you will have a testimony…Good luck!
caroline12
|
November 23, 2017
Hello every one. I'm from US-Dallas. I'm am so excited am a Complete woman Again, I Was Infected With Herpes virus since 3 Years now I am devastated and am finding it hard to cope i was emotionally down I Have Been Seriously Praying To God And Searching For Cure.So as I was browsing through the Internet one day, I came across a website that suggested that Dr.HOPE can help cure any type of virus like Herpes, Hiv/Aids cancer and Asthma…e.t.c And I Contacted Him, He Sent Me A Medicine And Directed Me On How I Will Take The Medicine For 21 Days, I Did So And Went For A Test And My Result Came Out As Negative. I Am So Happy, I Shared Tears Of Happiness And I Have Taken It Upon My Self To Always Testify About How God Used Dr.HOPE To Solve My Problem. I Am A Clean woman Now, Without Any Virus If You Are Infected With Any Disease Like HIV AIDS, CANCER ,HERPES Or Any Other Disease You Can Also Be Happy Like Me,contact him now via Email:dr.hopesolutionhome@hotmail.com or call him on 2348139560075
anonymous
|
November 22, 2017
Am here to testify of the miraculous work of a great traditional doctor called DR.ZUKU ..I have been suffering from Herpes since last 2 years with my Husband but today I am happy that am cure from it with the herbal medicine made by Dr.ZUKU the great healer, I was browsing the internet searching for help when I came across a testimony shared by someone on how Dr.ZUKU cure her from Herpes Disease. I quickly contacted him to get the cure and today i am now free from the Virus, I am so much happy today that we have someone like this great healer out there, so' people out there kindly contact this great doctor on his email address please sir keep your good work cause there are people out there who is in need of your healing medicine .once more contact him now drzukuspelltemple@gmail.com call or text 16177296273 Dr.Zuku can prepare Herbal medicine for all kind of disease. HIV. CANCER. HEPATITIS B.DIABETES.COLD SORES. Syphilis. HBV, HPV, STD's And many more.contact Dr.Zuku to get your healing.
MR BEN
|
November 22, 2017
contact peterwiseherbalcenter@gmail.com

he just helped me get rid of herpes simplex virus !

I've been trying for months to get a cure to my herpes but couldn't get any. i have cried every week about this and i searched and searched for a possible cure and who would help me but i got scammed by a lot of them, i felt like i couldn't live

then i came across a testimony of one Mrs grace who was cured of ALS BY this wonderful and understanding herbal healer

peter wise and immediately i contacted him and explain my condition to him he sent me his powerful herpes simplex virus herbs which i took and in less than a month all my body got healed , i couldn't believe it, now am free of herpes,totally free no more pains and my mouth , my genital area are so fresh and clear now ,

thank you so much peter wise! call or WHATSAPP him now at 2349059610643

if you have ANY problem and need it solved

DON'T TRUST ANY OF THE DOCTORS HERE EXCEPT THIS MAN (Peterwise) IS GENUINE
rhonda brain
|
November 21, 2017


GET RID OF HERPES BY A HERBALIST DOCTOR CALL DR Hope.

" I want to give almighty praise to DR Hope who cure me from herpes. He is a great man who God send from heaven to save people’s life, when i contacted this deadly virus disease i thought that was the end of the world for me little did I know that there is a man called DR Hope who has made a breakthrough in the cure of herpes with the help of herbal treatment which I confided in a friend in south Africa he told me about this man called DR Hope and how he cured the mum and dad from genital herpes after many years of living with this deadly diseases he told me of the cost and procedure I felt it worth a try after I have been spending so much on medical drugs to make me live like every normal human being so I contacted DR Hope and did as he commanded without missing his words he did all he needed to do and sent me the herbal medication via DHL shipment I took it as he directed it was exactly 19 days as DR Hope has spoken when he emailed me and told me to go for a check up again and I went to my greatest surprise it was negative I felt it was a dream so I went to three different hospital and it was still negative then I cried out in a loud voice and people gathered in the hospital and I told them my story in tears how this man called DR Hope have saved my life and they started demanding for his mail to contact him it was only last week my friend monica who was herpes positive came back from visiting DR Hope as a healthy woman I told her about DR Hope you can reach him through his email address dr.hopesolutionhome@hotmail.com. he never fails hold done my friend don't cry no more when our helper is here I believe in him he am sure you will be lucky as I am too just email him on dr.hopesolutionhome@hotmail.com he is a savior of life. any DISEASE: you have will be cure by DR Hope

1. HIV/AIDS

2. HERPES

3. CANCER

4. ALS

5. Hepatitis B

6. Diabetes

7 Genital herpes

8 if anyone want to get how Menstruation back again

email: dr.hopesolutionhome@hotmail.com or call 2348139560075
milleer
|
November 21, 2017
I NEVER BELIEVED BUT NOW I BELIEVE EVERY WORD THAT DR HOPE SAYS AND EVERY BODY NEEDS TO KNOW ABOUT HIM.

I am here to give my testimony about Dr Hope who helped me.. i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by Dr Hope, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how Dr Hope cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took for just 2 weeks and it seriously worked for me, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that there is no cure for herpes that is Not true just contact him and get cure from Dr Hope healing cure of all kinds of sickness you may have. Remember delay in treatment leads to death.. email: dr.hopesolutionhome@hotmail.com or call him on 2348139560075
luciana brandy
|
November 21, 2017
Hello everyone, I want to testify of how i got cured from Hepatitis B with the help of a great Dr eveoko I got diagnosed of Hepatitis B in 2013 I have visited several hospitals but all to no avail, my world was gradually coming to an end until i saw a post in a health forum about a herbal cure who casts herbal spells to cure all kind of deadly diseases including Hepatitis , ALS, MND, Epilepsy, Leukemia, Asthma, Cancer, Herpes,HIV/AIDS, at first i doubted if it was real but decided to give it a try, when i contact this herbal Dr. eveoko via his email:eveokoherbalhaome@outlook.com , and explain my problem to him and he told me that he is going to prepare a herbal spell portion and sent it to me, when i received this herbal spell portion, he gave me step by step instructions on how to use it, when i applied it as instructed, so i went for check up and i was cured of this deadly disease within a week, I am now free from Hepatitis B. All thanks to Dr.eveoko . Contact this great herbal cure via his email eveokoherbalhome@outlook.com or whats app him on 2348022010422 for more info lucianabrandy0@gmail.com
howard vivian
|
November 20, 2017
I'm here to testify about what DR. MAGGI did for me. I have been suffering from (GENITAL HERPES VIRUS) disease for the past 3 years and had constant pain and inching, especially in my private part. During the first year, I had faith in God that i would be cured someday.This disease started circulating all over my body and I have been taking treatment from my doctor, few weeks ago I came across a testimony of Rose Smith on the internet testifying about a Man called DR. MAGGI on how he cured her from 7 years HSV 2. And she also gave the email address of this man, advise anybody to contact him for help on any kind of diseases that he would be of help, so I emailed him telling him about my (HSV 2) he told me not to worry that I was going to be cured!! Well, I never doubted him I have faith he can cure me too,, DR. MAGGI prepared and sent me Healing Oil, Soap, roots and herbs which I took. In the first one week, I started experiencing changes all over me, after four weeks of using his Roots/ Herbs, Oil and Soap, I was totally cured. no more inching , pain on me anymore as DR. MAGGI assured me. After some time I went to my doctor to do another test behold the result came out negative. So friends my advise is if you have such disease or know anyone who suffers from it or any other disease like HPV, HBV, HIV, ALS, HBP, CANCER etc. you can contact DR. MAGGI for help via email} Maggiherbalcenter@gmail.com call 2347057375409 or whatsaap him through his mobile} 2348148487280. You can also email me on howardvivian222@gmail.com. I may not reply your mail immediately but at my leisure i will do so, Thanks once again DR. MAGGI for making me a happy woman again.
Marian Talley
|
November 20, 2017
This is real take it serious, who will believe that a herbal can cure six years HIV in my body, i never believe that this will work i have spend a lot when getting drugs from the hospital to keep me healthy, what i was waiting for is death because i was broke, one day i hard about this great man who is well know of HIV and cancer cure, i decided to email him, unknowingly to me that this will be the end of the HIV aids in my body, he prepare the herb for me, and give me instruction on how to take it, at the end of the two week, he told me to go to the hospital for a check up, and i went, surprisingly after the test the doctor confirm me negative, i thought it was a joke, i went to other hospital was also negative, then i took my friend who was also HIV positive to the Dr, after the treatment she was also confirm negative . He also have the herb to cure cancer please i want every one with this virus to be free, that is why am dropping his email address, dr.atakumaoracle@outlook.com and his contact 2347064693371 dr.atakumaoracle@outlook.com do email him he is a great man. the government is also interested in this DR, thank you for saving my life, and I promise I will always testify for your good work add him now on whatsapp 2347064693371
Trending