Diabetes can lead to Alzheimer’s disease, La Jolla researchers find
by HANNA LAUKKANEN
Published - 05/02/16 - 10:20 AM | 12137 views | 320 320 comments | 27 27 recommendations | email to a friend | print
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
slideshow
The workable human brain wasn’t created to last 70 to 90 years. That’s why our brains have different neurologic diseases when we age, like Parkinson's or Alzheimer's. Senior associate Karthik Bodhinathan and postdoctoral associate Mohammed Waseem Akhtar are researching new medical care for Alzheimer’s disease at La Jolla’s Sanford Burnham Prebys Medical Discovery Institute.

“There aren’t very good drugs out there,” Bodhinathan explains, “and even the ones that are out, they hit multiple targets, which mean they cure what you need but also create side effects, like depression and suicidal behavior. My job is to see if we can refine them.”

Akhtar is finding out more about the link between Alzheimer's and diabetes.

“Generally,” he says, “the people with diabetes have roughly two times higher the risk of developing Alzheimer's disease.”

There are several reasons for that, he says, but the main reason centers on the sugar level in diabetic patient. High levels affect neuronal function and causes dysfunction in the powerhouses of the brain.

“In the diabetic brain, you see that they decline in learning and memory, which is what you see in an Alzheimer’s brain,” Akhtar notes.

Bodhinathan is researching the chemicals that affect the brain in prior unknown ways. It’s a big challenge, he says, because most times the drugs don’t do what researchers predict. Researchers change the chemistry, fueling a lengthy retesting process.

“I’m trying to see if we can use the brain’s different mechanism to clear these toxic proteins in the brain,” Bodhinathan says. “They attract more proteins, and they become this big gob in the brain – and we believe that once we attack those clusters, we will be able to cure the disease.”

In a related development, the U.S. Food and Drug Administration has approved Acadia Pharmaceutical’s Nuplazid drug for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. In 2014 the FDA designated Nuplazid as a “breakthrough therapy” for this condition.

Acadia, based in San Diego, plans in June to make Nuplazid commercially available to patients suffering from hallucinations and delusions associated with Parkinson’s disease psychosis in the United States.

According to the National Parkinson Foundation, about 1 million people in the United States and from 4 to 6 million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, characterized by hallucinations and delusions. This is associated with significant caregiver burden and is a major reason for nursing home placement among Parkinson’s patients.

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ERWIN ERIN
|
9 Hours Ago
Hello Everyone, my names is Erwin Erin, i m from Florida USA. I want to share my testimonies to the general public on how this great man called Dr Maggi cure my herpes. I have been a HERPES patient for over 7 Months and i have been in pains until i came across this lady when i traveled to Africa for Business trip who happen to once been a herpes patient, i explained every thing to her and she told me that there is this Great Dr that help her to cure her herpes and she gave me his email address for me to contact and i did as she instructed. And the man Dr Maggi told me how much to buy the herpes herbal medication and how i will get it, which i did. And to my greatest surprise that i took the Herpes herbal medicine for just one week and behold i went for a herpes test, for to my greatest surprise for the Doctor confirmed me to herpes free and said that i no longer have herpes in my system and till now i have never felt any pains nor herpes again, so i said i must testify the goodness of this man to the general public for if you are there surfing from this Herpes problems or any deadly disease or other disease for i will advice you to contact him on his working email: Maggiherbalcenter@gmail.com and i assure you that he will help you just as he did for me okay contact him on his email: Maggiherbalcenter@gmail.com THESE ARE THE THINGS DR MAGGI DOES 1. HERPES 2. LASSA FEVER 3. GONORRHEA 4. HIV/AIDS 5. LOW SPERM COUNT 6. MENOPAUSE DISEASE 7. EPILEPSY 8. ASEPSIS 9. CANCER 10. ANXIETY DEPRESSION 11. PREGNANCY PROBLEM 12. SHORT SIGHTEDNESS PROBLEM 14. Male menopause 15. Menopause - male 16. Menopause - peri 17. Menstruation problems 18. Mercury Poisoning 19. Migraine 20. Miscarriage 21. Mites (demode x mites) 22. Mites (scabies mites) 23. Motion sickness 24. Mouth ulcer 25. MRSA 26. Multiple sclerosis 27. Muscle cramps 28. Myodesopsia 29. Stroke 30. He can as well cast and remove spell or whatsapp him on 1(306) 993-9253 or text 1(662)967-1783.and you can also visit him on his webs:drmaggiherbalcenter.webs.com.

celina jolly
|
11 Hours Ago
I was cured of HIV with the used of natural herbs. My name is celina jolly and am from US. I love herbs so much. Most times, injection and drugs are just a waste of time. I was cured 8 months ago, i suffered from HIV for 13 yrs but with the help of Dr.Ogun herbal medicine, i was cured within few weeks of drinking the herbs he sent to me through courier delivery service. This same doctor also cured my Aunty from herpes, as soon as i heard she had herpes, i quickly refer her to Dr.Ogun and she was cured too after drinking his herbs.I have referred more than 15 persons to Dr.Ogun and they were all cured from their various illness. Have you taken herbs before?. You have spent so much money on drugs,injections,surgeries etc and yet you have no good result to show for it. Contact Dr. Ogun now, he is a herbalist doctor, i assured you of a cure if you drink his natural herbs. Dr.Ogun have herbs that cures Hiv, Herpes, diabetics, asthma, hepatitis, HBP, STD, cancer, chronic, etc. Contact Dr ogun through his Email address on: drogun62@gmail.com or WHATSAPP/CALL him on 2348104991149 . Please share the good news to other people once you are cured.
HOWARD VIVIAN
|
14 Hours Ago
I’m here to testify about what DR. MAGGI did for me. I have been suffering from (GENITAL HERPES VIRUS) disease for the past 3 years and had constant pain and inching, especially in my private part. During the first year, I had faith in God that i would be cured someday.This disease started circulating all over my body and I have been taking treatment from my doctor, few weeks ago I came across a testimony of Rose Smith on the internet testifying about a Man called DR. MAGGI on how he cured her from 7 years HSV 2. And she also gave the email address of this man, advise anybody to contact him for help on any kind of diseases that he would be of help, so I emailed him telling him about my (HSV 2) he told me not to worry that I was going to be cured!! Well, I never doubted him I have faith he can cure me too,, DR. MAGGI prepared and sent me Healing Oil, Soap, roots and herbs which I took. In the first one week, I started experiencing changes all over me, after four weeks of using his Roots/ Herbs, Oil and Soap, I was totally cured. no more inching , pain on me anymore as DR. MAGGI assured me. After some time I went to my doctor to do another test behold the result came out negative. So friends my advise is if you have such disease or know anyone who suffers from it or any other disease like HPV, HBV, HIV, ALS, HBP, CANCER etc. you can contact DR. MAGGI for help via email} Maggiherbalcenter@gmail.com or call 1(662) 967-1783 or whatsapp him on 1(306) 993-9253 You can also email me on howardvivian222@gmail.com. I may not reply your mail immediately but at my leisure i will do so, Thanks once again DR. MAGGI for making me a happy woman again. or visit his web:drmaggiherbalcenter.webs.com.
Karen Renee
|
15 Hours Ago
All thanks to Dr JOHN for curing my HIV with his healing spell, i do not have much to say but with all my life i will for ever be grateful to him and God Almighty for using Dr JOHN to reach me when i thought it was all over, today i am happy with my two kids and my husband after the medical doctor have confirmed my HIV status Negative,i have never in my life believed that HIV could be cured,but today i am a witness of it,and with the help of Dr JOHN healing spell i was cured permanently, so i want to use this means to reach other persons who have this disease or any other deadly disease by testifying the power of Dr JOHN that all hope is not lost yet, try and get in contact with Dr JOHN and i am very sure you also will be cured permanently.you can email him through his personal email drjohnhivcurehome@gmail.com you can also text or call him through his mobile number OR /Whats App him on this number 2347064365391 I'm very grateful to him for curing my disease that's why i will keep on sharing this wonderful testimony....

Karen Renee
|
16 Hours Ago
All thanks to Dr JOHN for curing my HIV with his healing spell, i do not have much to say but with all my life i will for ever be grateful to him and God Almighty for using Dr JOHN to reach me when i thought it was all over, today i am happy with my two kids and my husband after the medical doctor have confirmed my HIV status Negative,i have never in my life believed that HIV could be cured,but today i am a witness of it,and with the help of Dr JOHN healing spell i was cured permanently, so i want to use this means to reach other persons who have this disease or any other deadly disease by testifying the power of Dr JOHN that all hope is not lost yet, try and get in contact with Dr JOHN and i am very sure you also will be cured permanently.you can email him through his personal email drjohnhivcurehome@gmail.com you can also text or call him through his mobile number OR /Whats App him on this number 2347064365391 I'm very grateful to him for curing my disease that's why i will keep on sharing this wonderful testimony....

Karen Renee
|
16 Hours Ago
All thanks to Dr JOHN for curing my HIV with his healing spell, i do not have much to say but with all my life i will for ever be grateful to him and God Almighty for using Dr JOHN to reach me when i thought it was all over, today i am happy with my two kids and my husband after the medical doctor have confirmed my HIV status Negative,i have never in my life believed that HIV could be cured,but today i am a witness of it,and with the help of Dr JOHN healing spell i was cured permanently, so i want to use this means to reach other persons who have this disease or any other deadly disease by testifying the power of Dr JOHN that all hope is not lost yet, try and get in contact with Dr JOHN and i am very sure you also will be cured permanently.you can email him through his personal email drjohnhivcurehome@gmail.com you can also text or call him through his mobile number OR /Whats App him on this number 2347064365391 I'm very grateful to him for curing my disease that's why i will keep on sharing this wonderful testimony....

ALEXIS TRAVIS
|
16 Hours Ago
I am here to give my testimony about Dr MAGGI who helped me in my life, i want to inform the public how i was cured from (HERPES SIMPLEX VIRUS) by dr MAGGI spiritual, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how dr MAGGI spiritual cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, my HERPES result came out negative. I am so happy as i am sharing this testimony. My advice to you all who thinks that their is no cure for herpes that is Not true just contact him and get cure from dr MAGGI spirirtual healing spell cure of all kinds of sickness you may have. 1) If you want your ex back. (2) if you always have bad dreams. (3) You want to be promoted in your office. (4) You want women/men to run after you. (5) If you want a child. (6) If you have (ALS)and you need total cure. (7) If you have an HIV and you want to be cure, {8} if you have diabetes and you need cure {9} if you have any kind of sickness there is cure {10} eczema cure Remember delay in treatment leads to death email him @ {Maggiherbalcenter@gmail.com}or you can also add him on whatsapp 1(306)993-9253 or call him 1(662)967-1783.
laras
|
18 Hours Ago


I was in trouble when my doctor told me that i have been diagnosed with

herpes and i know my family will face a serious problem . when i am gone i

lost hope and wept most of the time, but one day i was surfing the internet

i saw Dr. omohan herbal home contact number online i called him and he

guided me. i asked him for solutions and he started the remedy for my

health thank God,now everything is fine i am cured by Dr. omohan herbal

medicine am very thankful to Dr. omohan and very happy with my hobby and

family email him on (dromohanherbalmedicine@gmail.com) call/whatsapp number 2348164816038

He can as well cure the following disease;

Herpes,

Asthma,

Cancer,

HSV1, &

HSV2,

Hepatitis B,

HIV/AID ETC.

Karen Renee
|
20 Hours Ago
All thanks to Dr JOHN for curing my HIV with his healing spell, i do not have much to say but with all my life i will for ever be grateful to him and God Almighty for using Dr JOHN to reach me when i thought it was all over, today i am happy with my two kids and my husband after the medical doctor have confirmed my HIV status Negative,i have never in my life believed that HIV could be cured,but today i am a witness of it,and with the help of Dr JOHN healing spell i was cured permanently, so i want to use this means to reach other persons who have this disease or any other deadly disease by testifying the power of Dr JOHN that all hope is not lost yet, try and get in contact with Dr JOHN and i am very sure you also will be cured permanently.you can email him through his personal email drjohnhivcurehome@gmail.com you can also text or call him through his mobile number OR /Whats App him on this number 2347064365391 I'm very grateful to him for curing my disease that's why i will keep on sharing this wonderful testimony....

Karen Renee
|
21 Hours Ago
All thanks to Dr JOHN for curing my HIV with his healing spell, i do not have much to say but with all my life i will for ever be grateful to him and God Almighty for using Dr JOHN to reach me when i thought it was all over, today i am happy with my two kids and my husband after the medical doctor have confirmed my HIV status Negative,i have never in my life believed that HIV could be cured,but today i am a witness of it,and with the help of Dr JOHN healing spell i was cured permanently, so i want to use this means to reach other persons who have this disease or any other deadly disease by testifying the power of Dr JOHN that all hope is not lost yet, try and get in contact with Dr JOHN and i am very sure you also will be cured permanently.you can email him through his personal email drjohnhivcurehome@gmail.com you can also text or call him through his mobile number OR /Whats App him on this number 2347064365391 I'm very grateful to him for curing my disease that's why i will keep on sharing this wonderful testimony....

Karen Renee
|
21 Hours Ago
All thanks to Dr JOHN for curing my HIV with his healing spell, i do not have much to say but with all my life i will for ever be grateful to him and God Almighty for using Dr JOHN to reach me when i thought it was all over, today i am happy with my two kids and my husband after the medical doctor have confirmed my HIV status Negative,i have never in my life believed that HIV could be cured,but today i am a witness of it,and with the help of Dr JOHN healing spell i was cured permanently, so i want to use this means to reach other persons who have this disease or any other deadly disease by testifying the power of Dr JOHN that all hope is not lost yet, try and get in contact with Dr JOHN and i am very sure you also will be cured permanently.you can email him through his personal email drjohnhivcurehome@gmail.com you can also text or call him through his mobile number OR /Whats App him on this number 2347064365391 I'm very grateful to him for curing my disease that's why i will keep on sharing this wonderful testimony....

celina jolly
|
October 19, 2018
I was cured of HIV with the used of natural herbs. My name is celina jolly and am from US. I love herbs so much. Most times, injection and drugs are just a waste of time. I was cured 8 months ago, i suffered from HIV for 13 yrs but with the help of Dr.Ogun herbal medicine, i was cured within few weeks of drinking the herbs he sent to me through courier delivery service. This same doctor also cured my Aunty from herpes, as soon as i heard she had herpes, i quickly refer her to Dr.Ogun and she was cured too after drinking his herbs.I have referred more than 15 persons to Dr.Ogun and they were all cured from their various illness. Have you taken herbs before?. You have spent so much money on drugs,injections,surgeries etc and yet you have no good result to show for it. Contact Dr. Ogun now, he is a herbalist doctor, i assured you of a cure if you drink his natural herbs. Dr.Ogun have herbs that cures Hiv, Herpes, diabetics, asthma, hepatitis, HBP, STD, cancer, chronic, etc. Contact Dr ogun through his Email address on: drogun62@gmail.com or WHATSAPP/CALL him on 2348104991149 . Please share the good news to other people once you are cured.
welson anna
|
October 19, 2018
Am indeed very happy for the great help that Dr. Abaka rendered to me, I am here to give my testimony about a doctor who helped me in my life. I and my husband was infected with HERPES SIMPLEX VIRUS for the pass 3 years, we went to many hospitals for cure but there was no solution, on till one faithful day , we saw a blog whereby Dr.Abaka cured a woman who also had herpes affection,we (Me and My HUSBAND) decided to contact him which we did, he asked us to buy some items, unfailingly we sent him the money he will need in buying the items required , He caste the spell and sent me some herbs. He asked me to go for check-up after 14 days of casting the spell, Luckily for me we were tested herpes negative, now I believe all these Testimonies about him on the internet, he is truly a great man, if you are going through the same problem and you need help you can contact the great Herbalist(drabakaspelltemple@gmail.com) or phone 2349063230051
welson anna
|
October 19, 2018
Am indeed very happy for the great help that Dr. Abaka rendered to me, I am here to give my testimony about a doctor who helped me in my life. I and my husband was infected with HERPES SIMPLEX VIRUS for the pass 3 years, we went to many hospitals for cure but there was no solution, on till one faithful day , we saw a blog whereby Dr.Abaka cured a woman who also had herpes affection,we (Me and My HUSBAND) decided to contact him which we did, he asked us to buy some items, unfailingly we sent him the money he will need in buying the items required , He caste the spell and sent me some herbs. He asked me to go for check-up after 14 days of casting the spell, Luckily for me we were tested herpes negative, now I believe all these Testimonies about him on the internet, he is truly a great man, if you are going through the same problem and you need help you can contact the great Herbalist(drabakaspelltemple@gmail.com) or phone 2349063230051
Louis Angel
|
October 19, 2018
I'm giving a testimony about DR.JOHN the great Herbalist, he has the cure to all manner of diseases, he cured my herpes simplex virus, though I went through different website I saw different testimonies about different spell casters and herbalist, I was like: 'Many people's have the herpes simplex virus cure why are people still suffering from it?' I though of it, then I contact DR JOHN via email, I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared it (CURE) and sent it to me through Airfreight Online Courier Service for delivery, he gave my details to the Courier Office, they told me that 2-3 days I will receive the parcel and i took the medicine as prescribed by him and I went for check-up 2 week after finishing the medicine, I was tested herpes simplex virus negative, if you are herpes simplex virus patient do me a favor by you contacting him and I assure anyone who is suffering it,your problem will never remain the same again you will be cured.also DR JOHN help my sister husband to cure his HIV/AIDS he was suffering from it for the past 3 years, After he {cure} my herpes simplex virus, then my sister heard about it, she went home to tell her husband about DR JOHN then her husband email him and explain his problem to him, he also prepare herbal medicine and he use Airfreight courier service to sent him the herbal medicine and he instruct him on how he will be using it for 14 days, That on the 15 days of it, he should go and check his self in the hospital and he did as he was instructed by DR JOHN to GOD be the glory he was cure of his HIV/AIDS which he was suffering from for the past 3 years thanks to these great man we will ever remain grateful to you sir indeed might work you did in our families. When you contact him, make sure you tell him that I refer you.. contact him via: drjohnhivcurehome@gmail.com or whats-app his telephone number 2347064365391
Louis Angel
|
October 19, 2018
I'm giving a testimony about DR.JOHN the great Herbalist, he has the cure to all manner of diseases, he cured my herpes simplex virus, though I went through different website I saw different testimonies about different spell casters and herbalist, I was like: 'Many people's have the herpes simplex virus cure why are people still suffering from it?' I though of it, then I contact DR JOHN via email, I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared it (CURE) and sent it to me through Airfreight Online Courier Service for delivery, he gave my details to the Courier Office, they told me that 2-3 days I will receive the parcel and i took the medicine as prescribed by him and I went for check-up 2 week after finishing the medicine, I was tested herpes simplex virus negative, if you are herpes simplex virus patient do me a favor by you contacting him and I assure anyone who is suffering it,your problem will never remain the same again you will be cured.also DR JOHN help my sister husband to cure his HIV/AIDS he was suffering from it for the past 3 years, After he {cure} my herpes simplex virus, then my sister heard about it, she went home to tell her husband about DR JOHN then her husband email him and explain his problem to him, he also prepare herbal medicine and he use Airfreight courier service to sent him the herbal medicine and he instruct him on how he will be using it for 14 days, That on the 15 days of it, he should go and check his self in the hospital and he did as he was instructed by DR JOHN to GOD be the glory he was cure of his HIV/AIDS which he was suffering from for the past 3 years thanks to these great man we will ever remain grateful to you sir indeed might work you did in our families. When you contact him, make sure you tell him that I refer you.. contact him via: drjohnhivcurehome@gmail.com or whats-app his telephone number 2347064365391
Louis Angel
|
October 19, 2018
I'm giving a testimony about DR.JOHN the great Herbalist, he has the cure to all manner of diseases, he cured my herpes simplex virus, though I went through different website I saw different testimonies about different spell casters and herbalist, I was like: 'Many people's have the herpes simplex virus cure why are people still suffering from it?' I though of it, then I contact DR JOHN via email, I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared it (CURE) and sent it to me through Airfreight Online Courier Service for delivery, he gave my details to the Courier Office, they told me that 2-3 days I will receive the parcel and i took the medicine as prescribed by him and I went for check-up 2 week after finishing the medicine, I was tested herpes simplex virus negative, if you are herpes simplex virus patient do me a favor by you contacting him and I assure anyone who is suffering it,your problem will never remain the same again you will be cured.also DR JOHN help my sister husband to cure his HIV/AIDS he was suffering from it for the past 3 years, After he {cure} my herpes simplex virus, then my sister heard about it, she went home to tell her husband about DR JOHN then her husband email him and explain his problem to him, he also prepare herbal medicine and he use Airfreight courier service to sent him the herbal medicine and he instruct him on how he will be using it for 14 days, That on the 15 days of it, he should go and check his self in the hospital and he did as he was instructed by DR JOHN to GOD be the glory he was cure of his HIV/AIDS which he was suffering from for the past 3 years thanks to these great man we will ever remain grateful to you sir indeed might work you did in our families. When you contact him, make sure you tell him that I refer you.. contact him via: drjohnhivcurehome@gmail.com or whats-app his telephone number 2347064365391
Maris Zach
|
October 19, 2018
Greetings to the general public, Am Maris Zach, from USA Washington, i want to inform the general public on how i was cured of HERPES Simplex Virus by a Doctor called DR.TONY, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how DR.TONY cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, HERPES result came out negative. thank you so much DR.TONY God will give you everlasting life, you shall not die before your time for being a sincere and great man. Am so happy, you can also contact him if you have similar problem Email: drtonyherbalcenter@gmail.com you can contact me for more information email me on 2348154900380
Maris Zach
|
October 19, 2018
Greetings to the general public, Am Maris Zach, from USA Washington, i want to inform the general public on how i was cured of HERPES Simplex Virus by a Doctor called DR.TONY, i visited different hospital but they gave me list of drugs like Famvir, Zovirax, and Valtrex which is very expensive to treat the symptoms and never cured me. I was browsing through the Internet searching for remedy on HERPES and i saw comment of people talking about how DR.TONY cured them. when i contacted him he gave me hope and send a Herbal medicine to me that i took and it seriously worked for me, am a free person now without problem, HERPES result came out negative. thank you so much DR.TONY God will give you everlasting life, you shall not die before your time for being a sincere and great man. Am so happy, you can also contact him if you have similar problem Email: drtonyherbalcenter@gmail.com you can contact me for more information email me on 2348154900380
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