Diabetes can lead to Alzheimer’s disease, La Jolla researchers find
by HANNA LAUKKANEN
Published - 05/02/16 - 10:20 AM | 203 203 comments | 22 22 recommendations | email to a friend | print
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
slideshow
The workable human brain wasn’t created to last 70 to 90 years. That’s why our brains have different neurologic diseases when we age, like Parkinson's or Alzheimer's. Senior associate Karthik Bodhinathan and postdoctoral associate Mohammed Waseem Akhtar are researching new medical care for Alzheimer’s disease at La Jolla’s Sanford Burnham Prebys Medical Discovery Institute.

“There aren’t very good drugs out there,” Bodhinathan explains, “and even the ones that are out, they hit multiple targets, which mean they cure what you need but also create side effects, like depression and suicidal behavior. My job is to see if we can refine them.”

Akhtar is finding out more about the link between Alzheimer's and diabetes.

“Generally,” he says, “the people with diabetes have roughly two times higher the risk of developing Alzheimer's disease.”

There are several reasons for that, he says, but the main reason centers on the sugar level in diabetic patient. High levels affect neuronal function and causes dysfunction in the powerhouses of the brain.

“In the diabetic brain, you see that they decline in learning and memory, which is what you see in an Alzheimer’s brain,” Akhtar notes.

Bodhinathan is researching the chemicals that affect the brain in prior unknown ways. It’s a big challenge, he says, because most times the drugs don’t do what researchers predict. Researchers change the chemistry, fueling a lengthy retesting process.

“I’m trying to see if we can use the brain’s different mechanism to clear these toxic proteins in the brain,” Bodhinathan says. “They attract more proteins, and they become this big gob in the brain – and we believe that once we attack those clusters, we will be able to cure the disease.”

In a related development, the U.S. Food and Drug Administration has approved Acadia Pharmaceutical’s Nuplazid drug for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. In 2014 the FDA designated Nuplazid as a “breakthrough therapy” for this condition.

Acadia, based in San Diego, plans in June to make Nuplazid commercially available to patients suffering from hallucinations and delusions associated with Parkinson’s disease psychosis in the United States.

According to the National Parkinson Foundation, about 1 million people in the United States and from 4 to 6 million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, characterized by hallucinations and delusions. This is associated with significant caregiver burden and is a major reason for nursing home placement among Parkinson’s patients.

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Alisson Clarke
|
4 Hours Ago


Hello everyone, this is serious and wonderful,it is in deed unbelievable .My husband and i have has this scary virus for SOME time now, we suffered of this HERPES VIRUS for 1 and half years,we have hoped all our life for a cure,until the day a friend of my with this same HERPES VIRUS introduced me to this great herbal doctor that helped her restore her life again with herbal medication,who was sent by God to save mankind with his herbal medication,this Herbal doctor called Dr.William uses herbal and traditional medicine to cure people. we have spent so much on this virus looking for a cure, paying hospital bills for years but no improvement . my friend told me that this herbal man who cure people with herbal medicine. He cures all sickness, diseases, viruses, and infections with his different herbal curing medicine. The result that declares my husband and I healed was from a hospital here in New York, And the results of the test says my husband and i was okay. Dr William directed that I and my husband would be okay in 21 days if we uses the medicine as directed. And 21 days later, we went to confirm it from the central hospital and several test that was done says my we are fully healed. So we were cured by this herbal doctor in 21 days. This amaze me though. I would advice everyone to meet this Dr William who made my husband i healthy again. Meet Dr.William and set yourself and your love ones free. Doctor Williams email again DRWILLIAMOBOHSPELLHOME@GMAIL.COM call or whats app 2347065237363....
Monica Watson
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12 Hours Ago
Good day to all viewer online am Monica Watson From USA..Texas am so happy sharing this great testimony on how i was checking for solution in the internet then miraculously i came Across Dr.Zuku the powerful herbalist that Cure Numerous individuals Herpes Simplex Virus,so I contacted him base on the testimonies I?m seeing about him on the internet, I was cured too by him, kindly contact him today through his email he can help you..drzukuspelltemple@gmail.com and so he can cure types of diseases like,HEPATITIS B,DIABETICS,CANCER,HPV,LOW SPERM CAM.. all thank to you Dr Zuku for your kindly help in my life his Mobile number 16177296273
anonymous
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6 Hours Ago
I want to give a testimony about my HIV virus that was cured by a great spell caster Dr voodoo. Since last 4 months I have being a HIV AID patient. I never think I live long again and am so grateful about Dr voodoo who cured my HIV AIDS last week. I was in a great pain so I told one of my best friends; and she told me that there is a spell caster that can cure my HIV she read someone testimony from a website on-line on how Dr voodoo cure her from HIV AIDS and she also collected Dr voodoo website and email. She gave me Dr voodoo email, I emailed him he talked to me and he perform the necessary rituals and he told me that after two weeks I should go for a test. Which I did, when the doctor told me that am now a HIV negative I couldn't believe myself I went to see another doctor the result was still the same contact DR voodoo via email voodoospelltemple66@gmail.com You can also call him or add him on WhatsApp 2349061243458
susan lisa
|
17 Hours Ago
I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year, I had faith in God that I would be healed someday.This disease started to circulate all over my body and I have been taking treatment from my doctor, a few weeks ago I came on search on the internet if I could get any information concerning the prevention of this disease, on my search I saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man DR Alli and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so I wrote to DR Alli telling him about my (HERPES Virus) he told me not to worry that I was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later I started experiencing changes all over me as the DR assured me that I have cured, after some time i went to my doctor to confirmed if I have been finally healed behold it was TRUE, So friends my advice is if you have such sickness or any other at all you can email DR Alli on( Allispellhelp1@gmail.com sir I am indeed grateful for the help I will forever recommend you to my friends!!! with your lovely Email Address ( Allispellhelp1@gmail.com or you can also WhatsApp him on this number 2348100772528

Alisson Clarke
|
23 Hours Ago


Hello everyone, this is serious and wonderful,it is in deed unbelievable .My husband and i have has this scary virus for SOME time now, we suffered of this HERPES VIRUS for 1 and half years,we have hoped all our life for a cure,until the day a friend of my with this same HERPES VIRUS introduced me to this great herbal doctor that helped her restore her life again with herbal medication,who was sent by God to save mankind with his herbal medication,this Herbal doctor called Dr.William uses herbal and traditional medicine to cure people. we have spent so much on this virus looking for a cure, paying hospital bills for years but no improvement . my friend told me that this herbal man who cure people with herbal medicine. He cures all sickness, diseases, viruses, and infections with his different herbal curing medicine. The result that declares my husband and I healed was from a hospital here in New York, And the results of the test says my husband and i was okay. Dr William directed that I and my husband would be okay in 21 days if we uses the medicine as directed. And 21 days later, we went to confirm it from the central hospital and several test that was done says my we are fully healed. So we were cured by this herbal doctor in 21 days. This amaze me though. I would advice everyone to meet this Dr William who made my husband i healthy again. Meet Dr.William and set yourself and your love ones free. Doctor Williams email again DRWILLIAMOBOHSPELLHOME@GMAIL.COM call or whats app 2347065237363....



Roodmore Wesie
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September 21, 2017


Good day viewers.. please just read this, some times we just need to give a try of herbal Medicine to see for our self. I am very happy today that i do not listen to what people say if not i would have been a dead man by now. I was infected with DIABETES in 2013, i went to many hospitals for cure but there was no solution, so I was thinking how can I get a solution out so that my body can be okay. One day I was in the river side thinking where I can go to get solution. so at that moment i was doing some research about remedy for herpes on my cell phone, so i came across an articles about a lady testifying on how she get cured by the help of a doctor , so i have to write down the email contact of the doctor that he recommended which is on a very good day i decide to write to this doctor and explain how this virus is killing me slowing, after introducing myself to this doctor after some time i got a reply back from him, and he told me the important of his herbal medicine also how he has cure DIABETES and all kinds of virus, He told me all the things I need to do and also give me instructions to take, which I followed properly. Before I knew what gradually my body was getting recovery and i was feeling so different than ever after two weeks the DIABETES that was in my body got vanished. so if you are also heart broken and also need a help, you can also contact him Via or whatsapp 12675278976 and give a try i promise if you can stay in touch with Him through his contact email address stated here correctly you wont miss out okay here is the Email drolokumspelltemple@gmail.com or whatsapp 12675278976. contact his Africa office on whatsapp or call 2348158836673 Beware of copyright to this authentication.

lizzy dixon
|
September 21, 2017
Thanks to dr.ojoka for his good work I never believe that HIV has cure, I

was HIV positive over 3 year now before I came across a comment about how

dr.ojoka cure HIV and herpes disease but when I saw it i have it in mind

that he can’t cure HIV I just decided to give it a try I contact him that

night luckily to me he replied me, but I don’t believe him I thought it was

a scam but I still hold on to see the work of Dr ojoka if he is saying the

truth he ask for some details about me i gave him all he needed and I

waited to see his reply to my problem after all, he told me to go for check

up and I went for HIV test I cant believe I was negative,am so happy and

grateful to God for using Dr ojoka to cure me, that is the reason why i

decided to write this wonderful testimony of our i was cured, i recommend

Dr.ojoka to you all around the world,contact him on his Email dr.ojokarootandherbal@gmail.com or you can also reach him through thanks whatapp number 2348144172934

dr.ojoka for helping me at this young age if you need help contact,

He can also cure so many sickness like

(1) herpes(2) hiv(3) als(4) dick enlargement(5) hepatitis B(6) ALOPECIA(7) CANCER,(8) DIABETES,(9) HERPES CURE(10) GETTING YOUR LOVER OR HUSBAND BACK(11) IMPOTENCE,(12) BARENESS/INFERTILITY(13) DIARRHE (14) ASTHMA
susan lisa
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September 21, 2017
I have been suffering from (HERPES) disease for the last four years and had constant pain, especially in my knees. During the first year, I had faith in God that I would be healed someday.This disease started to circulate all over my body and I have been taking treatment from my doctor, a few weeks ago I came on search on the internet if I could get any information concerning the prevention of this disease, on my search I saw a testimony of someone who has been healed from (Hepatitis B and Cancer) by this Man DR Alli and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so I wrote to DR Alli telling him about my (HERPES Virus) he told me not to worry that I was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later I started experiencing changes all over me as the DR assured me that I have cured, after some time i went to my doctor to confirmed if I have been finally healed behold it was TRUE, So friends my advice is if you have such sickness or any other at all you can email DR Alli on( Allispellhelp1@gmail.com sir I am indeed grateful for the help I will forever recommend you to my friends!!! with your lovely Email Address ( Allispellhelp1@gmail.com or you can also WhatsApp him on this number 2348100772528
Barry White
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September 20, 2017


Big thanks to Dr. Clifford for the help he rendered to me, I was a HIV patient i saw a blog whereby Dr. Clifford cured HIV,i decided to contact him which i did, He prepared the herbs medicine and sent it to me and after i have used the herbs he sent to me he asked me to go for check-up after three days of using the herbs, Luckily for me i were tested HIV negative, now I believe all these Testimonies about him on the INTERNET, he is truly a great man.You can contact the great Herbalist and a spell caster on(drcliffordsolutioncenter62@gmail.com). or WhatsApp no, ( 2348105049840)
JAck SMITH
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September 20, 2017
I've seen the great importance of natural herbs and the wonderful work they have done in people's lives. I wonder why people still spend their money on surgery, injections and drugs each time they are sick. Natural herbs can cure all kinds of illness including herpes, diabetics, asthma, HIV, hepatitis, etc. I've seen it with my own eyes. I was cured of Herpes and my aunt and her husband were cured of HIV by high priest DR NORUWA who uses natural herbs to cure different kind of illness. He is also a spell caster who also help me cast a spell that bring my ex girlfriend back to me without any delay it was after he cured me of herpes that make me trust him and believe in him to also help me get my ex back and he did it for me. I broke up with my ex with just little misunderstanding hoping we will get back shortly,but things was growing worse until i contacted high priest who help me with his natural herbs to cure my herpes also help me with love spell to bring my ex back, without charging me any money for his work i only provide the items he needed to cast the spell for me, i have never believed in a spell caster until i come across High priest DR NORUWA, Well it will be of great sin if i should go out from here without dropping the contact of this great and world best famous spell caster, email him via DRNORUWASPELLHOME@GMAIL.com.

Robert Fred
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September 20, 2017
My Name is Robert Fred from Canada..it gives me great joy to share with you on how I was cured of a dreaded virus called HIV Disease by Dr.ZUKU,a powerful traditional herbalist.i have be suffered for 8years and till now i am still shocked but the good new is that Dr,ZUKU is the reason for my smile today. i don't know to explain how everything worked. the healing happened within the twinkle of my eye. after all the years of going from places to another for remedy. i got my cured finally. May God continue to bless his work and also to my best friend who searched him on his internet and directed me to contact him. after writing to him he prepared my herbal cure and how i am to use it and withing 2 weeks after using herbal remedy i went to check up and was found that my HIV Virus was gone and was negative.It is indeed a great news to those who must be suffering from one disease or virus, Dr Zuku is able to challenge that affliction. Why not visit him today through: drzukuspelltemple@gmail.com call or text for more information 16177296273
joel lisa
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September 20, 2017
Am Lisa by name, i was diagnosed with Herpes for 3years ago i lived in pain with the knowledge that i wasn't going to ever be well again i contacted so many herbal doctors on this issue and wasted a large sum of money but my condition never got better i was determined to get my life back so one day i saw mr Brown post on how Dr Aba saved him from the VIRUS with his herbal medicine i contacted Dr Aba on his email address dr.abaherbalhome@gmail.com we spoke on the issue i told him all that i went through and he told me not to worry that everything will be fine again so he prepared the medicine and send it to me through courier service and told me how to use it,after 14days of usage I went to see the doctor for test ,then the result was negative,am the happiest woman on earth now. this testimony is real.thanks to Dr Aba God bless you. you can also reach him on his whatsApp number 2348107155060
Harry Wayn
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September 20, 2017


i am Harry Wayn i have been with my girlfriend since June 2011 ..I just found out this past month that she is HIV positive I knew he was on med of all kinds wasn't exactly positive for what though...I finally sat Her down and talked to her and asked her to please tell me what the pills were for...she finally admitted in 95 she was told she was HIV positive ...she was afraid to tell me...she has been in the hospital twice near death ...that part I knew just didn't know the why...I love her with all my heart and can't leave her..but I am scared we have never practiced safe sex the whole time we have been together...I have been tested twice and am HIV free so far ...He appears to me to be in denial of her disease..she takes her med because i give them to her each day...I cant leave her i need her he needs me...we never talk about his disease..how can i make things more in the open with him? He has told me if i discuss this with anyone I will have to leave no if and or buts about it...so I haven't talked with anyone till now about it...also I know I am going to hear leave her immediately and I cant and won't do that.. but i.just had a good friendly ear who told me how doctor Okhihie help her cure her HIV virus she gave me the email address okhihiespelltemple@gmail.com i really contacted him he told me to get some items which he will use to prepare the herbal medicine, though i could not found those items over here he said i should send him the little money so that he can help me buy the item and proceed with the herbal medicine i was very happy i gladly send him the little money he prepare the herbal medicine and send it to me i gave it to my love she drank it for just three weeks every thing about her was fully okay then we both went to hospital for check up my love was found negative. so i want to use this great privilege to thank doctor Okhihie for my love because me and my love are living happily today.i will advice any body that is passing through such problem to contact him on his email okhihiespelltemple@gmail.com
laua22
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September 20, 2017
I am tina from USA , I Never believed i was ever going to be HIV Negative again,Dr okeke has given me reasons to be happy, i was HIV positive for 2years and all the means i tried treatment was not helpful to me, but when i came on the Internet i saw great testimony about Dr okeke on how he was able to cure someone from HIV, this person said great things about this man, and advice we contact him for any Disease problem that Dr okeke can be of help, well i decided to give him a try, he requested for my information which i sent to him,and he told me he was going to prepare for me a healing portion, which he wanted me to take for days,and after which i should go back to the hospital for check up, well after taking all the treatment sent to me by Dr okeke i went back to the Hospital for check up, and now i have been confirmed HIV Negative, friends you can reach Dr okeke on any treatment for any Disease he is the only one that can solve your problem, reach him on Dr okeke on his email writelovespell@gmail.com or call him or whatSapp him on 2348140443360 HE IS ALSO SPECIALISED TO CURE ANY KIND OF DISEASE

(1) CANCER,

(2) DIABETES,

(3) HERPES SIMPLEX DISEASE,

(4) URINARY TRACT INFECTION,

(5) CANCER,

(6) IMPOTENCE,

(7) BARENESS/INFERTILITY

(8) DIARRHEA

(9) ASTHMA...

(10)BRING BACK YOUR EX

(11) PENIS ELAGEMENT

(12) HSV

HE IS SOLUTION TO ALL YOUR PREDICAMENTS CONTACT him Email

writelovespell@gmail.com or call or whatsAP hin on 2348140443360

Doris carter
|
September 20, 2017
Hello everyone, Now this is to everyone out there with different health challenges, as I know there are still a lot of people suffering from different health issues and are therefore looking for solution. I bring you Good news. There is a man called Dr. Magana a herbal practitioner who helped cure me from Genital herpes, this i had suffered from for the past 2 years and have spent so much money trying to survive from it. I got my healing by taking the herbal medicine he sent to me to drink for about 9 days . 3 days after completion of the dosage, I went for a medical checkup and I was tested Genital Herpes NEGATIVE. I'm sharing this so that other people can know of this great healer called Dr Magana because I got to know him through a friend he cured from HIV. I was made to understand that he can cure several other deadly diseases and infections. Don't die in ignorance and don't let that illness take your life. Contact Dr. Magana through: maganasolutioncentre@gmail.com Be kind enough to share as you received.
glory allen
|
September 20, 2017
I have been suffering from (HERPES SIMPLEX VIRUS) for the past two years and had constant pain especially in my lip. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr Aba and she also gave the email address: dr.abaherbalhome@gmail.com of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. Aba telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Dr assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email:: dr.abaherbalhome@gmail.com or whatsApp his number on 2348107155060
gilberto melo
|
September 20, 2017
I was diagnosed of herpes in 2015 and I tried all possible means to get cure but all to no avail until i saw a post in a health forum about a herbal doctor from Africa who prepare herbal medicine to cure all kind of diseases including herpes virus, at first i doubted if it was real but decided to give it a try, when i contact this herbal doctor via his email i bought the herpes herbal medicine and received it through DHL within 7 days and used it as prescribed, i tested negative to hepatitis b virus within 3 weeks of usage, Do not loose hope too soon contact him If you need his help you can Email him @ dremuahelphome@outlook.com or dremuahelphome@gmail.com for easy and fast communication you can also call or add him on whats-app with this number 2347063628174 and i am confident he will help you too.
sarahjesae
|
September 20, 2017
I want to give a testimony on how I got cured from Parkinson's disease. Few months back I was having some symptoms . I went to see a doctor and many blood tests was done on me, later on I was told I had Parkinson's disease. My doctor told me that there's no cure for Parkinson's disease I felt bad, I went online searching for a possible cure for Parkinson's disease, I saw a post of Dr Bello, a herbal doctor that's helping people get cured from Parkinson, HPV, HIV, HEPATITIS B, CANCER e.t.c. i contacted him and told him how I'm feeling he said his herbal medicine can cure me. He sent me the medicine via Dhl delivery service and I received the medicine some days after he sent it, i took the medicine as prescribed by him. Before the completion of the medication the symptoms stopped. I went to the doctor and carried out another blood test, surprisingly I was Negative. I haven't had any symptoms anymore. Dr. Bello is great and you can contact via (bellospelltemple@gmail.com) whatsApp him via 2348147271779;
sarahjesae
|
September 20, 2017
I want to give a testimony on how I got cured from Parkinson's disease. Few months back I was having some symptoms . I went to see a doctor and many blood tests was done on me, later on I was told I had Parkinson's disease. My doctor told me that there's no cure for Parkinson's disease I felt bad, I went online searching for a possible cure for Parkinson's disease, I saw a post of Dr Bello, a herbal doctor that's helping people get cured from Parkinson, HPV, HIV, HEPATITIS B, CANCER e.t.c. i contacted him and told him how I'm feeling he said his herbal medicine can cure me. He sent me the medicine via Dhl delivery service and I received the medicine some days after he sent it, i took the medicine as prescribed by him. Before the completion of the medication the symptoms stopped. I went to the doctor and carried out another blood test, surprisingly I was Negative. I haven't had any symptoms anymore. Dr. Bello is great and you can contact via (bellospelltemple@gmail.com) whatsApp him via 2348147271779;
sarahjesae
|
September 20, 2017
I want to give a testimony on how I got cured from Parkinson's disease. Few months back I was having some symptoms . I went to see a doctor and many blood tests was done on me, later on I was told I had Parkinson's disease. My doctor told me that there's no cure for Parkinson's disease I felt bad, I went online searching for a possible cure for Parkinson's disease, I saw a post of Dr Bello, a herbal doctor that's helping people get cured from Parkinson, HPV, HIV, HEPATITIS B, CANCER e.t.c. i contacted him and told him how I'm feeling he said his herbal medicine can cure me. He sent me the medicine via Dhl delivery service and I received the medicine some days after he sent it, i took the medicine as prescribed by him. Before the completion of the medication the symptoms stopped. I went to the doctor and carried out another blood test, surprisingly I was Negative. I haven't had any symptoms anymore. Dr. Bello is great and you can contact via (bellospelltemple@gmail.com) whatsApp him via 2348147271779;
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