Diabetes can lead to Alzheimer’s disease, La Jolla researchers find
by HANNA LAUKKANEN
Published - 05/02/16 - 10:20 AM | 15042 views | 537 537 comments | 27 27 recommendations | email to a friend | print
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
Researcher Karthik Bodhinathan measures a mouse brain as part of his efforts to stop Alzheimer’s disease. PHOTO BY HANNA LAUKKANEN
slideshow
The workable human brain wasn’t created to last 70 to 90 years. That’s why our brains have different neurologic diseases when we age, like Parkinson's or Alzheimer's. Senior associate Karthik Bodhinathan and postdoctoral associate Mohammed Waseem Akhtar are researching new medical care for Alzheimer’s disease at La Jolla’s Sanford Burnham Prebys Medical Discovery Institute.

“There aren’t very good drugs out there,” Bodhinathan explains, “and even the ones that are out, they hit multiple targets, which mean they cure what you need but also create side effects, like depression and suicidal behavior. My job is to see if we can refine them.”

Akhtar is finding out more about the link between Alzheimer's and diabetes.

“Generally,” he says, “the people with diabetes have roughly two times higher the risk of developing Alzheimer's disease.”

There are several reasons for that, he says, but the main reason centers on the sugar level in diabetic patient. High levels affect neuronal function and causes dysfunction in the powerhouses of the brain.

“In the diabetic brain, you see that they decline in learning and memory, which is what you see in an Alzheimer’s brain,” Akhtar notes.

Bodhinathan is researching the chemicals that affect the brain in prior unknown ways. It’s a big challenge, he says, because most times the drugs don’t do what researchers predict. Researchers change the chemistry, fueling a lengthy retesting process.

“I’m trying to see if we can use the brain’s different mechanism to clear these toxic proteins in the brain,” Bodhinathan says. “They attract more proteins, and they become this big gob in the brain – and we believe that once we attack those clusters, we will be able to cure the disease.”

In a related development, the U.S. Food and Drug Administration has approved Acadia Pharmaceutical’s Nuplazid drug for the treatment of hallucinations and delusions associated with Parkinson’s disease psychosis. In 2014 the FDA designated Nuplazid as a “breakthrough therapy” for this condition.

Acadia, based in San Diego, plans in June to make Nuplazid commercially available to patients suffering from hallucinations and delusions associated with Parkinson’s disease psychosis in the United States.

According to the National Parkinson Foundation, about 1 million people in the United States and from 4 to 6 million people worldwide suffer from Parkinson’s disease. An estimated 40 percent of these patients have Parkinson’s disease psychosis, characterized by hallucinations and delusions. This is associated with significant caregiver burden and is a major reason for nursing home placement among Parkinson’s patients.

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rosesharon
|
February 15, 2019
My names is Sandra I was diagnosed of Herpes disease 2017, I was told by my doctor that there’s no cure. I was so worried anytime i think about it,i was spending alot on medication,and i was sacked from work,because i was always sick,infact my life was a mess..i was just researching online I saw a lot of testimonials about Dr Odila on how he uses herbal medicine to cure so many deadly disease …. I contacted him via email: drodilaherbalhome@gmail.com and told him my problems, then he said i will be totally cured within 14days,my heart was full on joy when he said that i will be totally cured within 14days ,i just had faith and believe,then i purchased the herbal medicine and sent him my details such as NAME,HOME ADDRESS,PHONE NUMBER ,Then Dr Odila sent me the herbal medicine to me through courier service and I used the herbal medicine for good 14days, then I went for check-up and my doctor confirmed thats am totally free from Herpes it work like a miracle to me ,please viewers out there this is real am so happy to share this testimony .thanks to perfect health GOD WILL BLESS U . contact him through drodilaherbalhome@gmail.com or whatsapp 2348159047935. here is my private email sandraprecious100@gmail.com
joel lisa
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February 14, 2019
Am Lisa by name, i was diagnosed with Herpes for 3years ago i lived in pain with the knowledge that i wasn't going to ever be well again i contacted so many herbal doctors on this issue and wasted a large sum of money but my condition never got better i was determined to get my life back so one day i saw mr Brown post on how Dr Aba saved him from the VIRUS with herbal medicine i contacted Dr Aba on his email address dr.abaherbalhome@gmail.com we spoke on the issue i told him all that i went through and he told me not to worry that everything will be fine again so he prepared the medicine and send it to me through courier service and told me how to use it,after 14days of usage I went. to see the doctor for test ,then the result was negative,am the happiest woman on earth now. this testimony is real.thanks to Dr Aba God bless you. you can also reach him on his whatsApp number 2348107155060
Rita Dominic
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February 12, 2019
My Name is Rita Dominic from USA/TEXAS, Herbal Medicine is a good remedy for Herpes Virus , I was a carrier of Herpes and I saw a testimony on how Dr balogun cure Herpes Virus, I decided to contact him, I contacted him and he guided me. I asked him for solutions and he started the remedies for my health. After he finish he sent me the herbs which i took for 2 week before going for a check up and getting there i could not believe that i was confirm Herpes Negative after the test,Today i am so happy because i'm free from herpes disease with the help of Dr balogun. Thank God now everything is fine, I'm cured by Dr balogun herbal medicine, I'm very thankful to God for making it possible you can reach him on his email i strongly recommend him to any one out there looking for a cure balogun.herbalsolutioncenter@gmail.com or Call/Whats app him on 2349064881054
summer jessic
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February 10, 2019
I am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Isibor, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive diseases his email is: drisiborspellhome@gmail.com or you can call or whatsApp his mobile number on 2348107855231.
Ava Mia
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February 08, 2019
God bless Dr Lobo for his marvelous work in my life, I was diagnosed of HERPES since 2017 and I was taking my medications, I wasn't satisfied i needed to get the HERPES Cured out of my system, I searched about some possible cure for HERPES i saw a comment about Dr Lobo, how he cured HERPES with his herbal medicine, I contacted him and he guided me. I asked for solutions, he started the remedy for my health, he sent me the medicine through UPS SPEED POST. I took the medicine as prescribed by him and 2weeks later i was cured from HERPES, Dr Lobo truly you are so great and powerful in spiritual works, do you acneed his help also? Why don't you contact him through his VIA EMAIL: (Loboherbalcure@gmail.com) whatsapp him on 2349078118695
Panshak Zamani
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February 08, 2019
I was diagnosed of herpes 3 years ago, the doctor said there are no possible cure for the virus. But i never gave up hope of getting cured. i have been living with it taking acyclovir to prevent outbreaks. I have been doing everything possible to get cured, so i never stopped doing research about finding a cure, i came across testimonies of people getting cured by Dr. Okasi herbal medicine. I contacted him through his website: okasiherbalsolution.webs.com, we talked on phone and i discovered he was genuine. I gave it a try and got the medicine from him, took it has he has prescribed and i'm so happy to say i'm completely cured, i went back to my doctor to confirm it. It's so amazing, a thing of joy. Dr Okasi herbs medicine is capable of curing HSV 1&2 completely. contact him today Email: okasiherbalsolution@outlook.com
rosesharon
|
February 09, 2019
Having herpes is not the end of life there many treatment to cure herpes infection with the help of Dr Edidia herbal product.

I was positive to the deadly virus called HERPES and i lost hope because i

was out casted and rejected even by my closet friends.

i searched on-line to know and enquirer about cure for HERPES and i read

someone testimony on how he was cured from HSV-2 so i decided to contact

the same herbalist Call Dr Edidia because i know that nature has the power

to heal everything.

i contacted him to know how he can help me and he told me never to worry

that he will help me with the natural herbs from God!

after 2 days of contacting him, he told me that the cure has been ready and

he sent it to me via UPS SPEED POST and it got to me after 3 days!

i used the medicine as he instructed me (MORNING and EVENING) and i was

cured!

its really like a dream but i am so happy!

thats the reason i decided to also add more comment of Him so that more can

be saved just like me!

and if you need his help, you can email him on dredidiaherbalhome@gmail.com

or whatsapp 2349074505296

here is the Dr website http://dredidiaherbalhome.weebly.com/

https://dr-edidia-herbal-home.business.site/

I,m rosesharon and you can get intouch with me via rosesharon915@gmail.com also view website to know him
Rose daniel
|
February 07, 2019
I still don’t know the right words to express my gratitude to this great man Dr. Aba. After been diagnosed of HERPES SIMPLEX VIRUS in 2months ago, i was given so many health prescription and advice with no improvement, I totally lost hope, until i found testimonies of Great Dr. aba online research and on Facebook, Like anybody would be, I was very skeptical about contacting him, but i later did and he opened up to me and told me what was involved and he started the remedies for my health. Thank God, i was cured from herpes by the herbal medication I received from him. I never thought that herpes can be cured, from the bottom of my heart I'm truly grateful,i pray you have long life so you can help many more people on earth with your herbal medical support, You can Email him via email dr.abaherbalhome@gmail.com or for easy and fast communication you can also call or add him on whats-app with this mobile number 2348107155060, one thing i love most about DR aba is honestly, and he is very polite with his patience, everything he told me was what he did, and his herbal medicine are very affordable.
rosesharon
|
February 07, 2019
Having herpes is not the end of life there many treatment to cure herpes infection with the help of Dr Edidia herbal product.

I was positive to the deadly virus called HERPES and i lost hope because i

was out casted and rejected even by my closet friends.

i searched on-line to know and enquirer about cure for HERPES and i read

someone testimony on how he was cured from HSV-2 so i decided to contact

the same herbalist Call Dr Edidia because i know that nature has the power

to heal everything.

i contacted him to know how he can help me and he told me never to worry

that he will help me with the natural herbs from God!

after 2 days of contacting him, he told me that the cure has been ready and

he sent it to me via UPS SPEED POST and it got to me after 3 days!

i used the medicine as he instructed me (MORNING and EVENING) and i was

cured!

its really like a dream but i am so happy!

thats the reason i decided to also add more comment of Him so that more can

be saved just like me!

and if you need his help, you can email him on dredidiaherbalhome@gmail.com

or whatsapp 2349074505296

here is the Dr website http://dredidiaherbalhome.weebly.com/

I,m rosesharon and you can get intouch with me via rosesharon915@gmail.com also view website to know him

https://dredidiaherpescure.blogspot.com/

https://dr-edidia-herbal-product.business.site

here is my whatsapp contact 1(647) 3607 357

Panshak Zamani
|
February 08, 2019
I was diagnosed of herpes 3 years ago, the doctor said there are no possible cure for the virus. But i never gave up hope of getting cured. i have been living with it taking acyclovir to prevent outbreaks. I have been doing everything possible to get cured, so i never stopped doing research about finding a cure, i came across testimonies of people getting cured by Dr. Okasi herbal medicine. I contacted him through his website: okasiherbalsolution.webs.com, we talked on phone and i discovered he was genuine. I gave it a try and got the medicine from him, took it has he has prescribed and i'm so happy to say i'm completely cured, i went back to my doctor to confirm it. It's so amazing, a thing of joy. Dr Okasi herbs medicine is capable of curing HSV 1&2 completely. contact him today Email: okasiherbalsolution@outlook.com.....
gabe frank
|
February 05, 2019
All these post about HERBAL MEDICINE and spell caster are scammer and fake trying to collect money all in the name of HERPES cure and when you contact them, they will be asking for your name, pictures, country, phone number, occupation and when you have given them all the information, they will be asking for money. I was once suffering from GENETIC HERPES and i spent a lot of money going from one herbal doctor to another but they all scam and take my money away until i came in contact with this powerful one called Dr Iyoha who cured me from Herpes with his herbal medication ,after Dr Iyoha has finished preparing the herbal medicine, he asked me to send him my residential address, so that he will send the herbal medicine to me via D.H.L so i did. 2 days later, i received the herbal medicine and i had to follow the instructions he gave to me on how i will apply it. 2 weeks later i went to hospital for test and according to the test done by the Medical doctor Matthew it stated that i was cured. So viewers be wise and beware of fake spell casters and fake herbal doctors, they are all over the internet trying to steal from poor people. I will drop you the phone number of this powerful herbal doctor just in case you wish to contact him for help call his number (407) 337-9869

Dr Iyoha

CAN AS WELL CURE THE FOLLOWING DISEASE:-

1. HERPES

2. LASSA FEVER

3. GONORRHEA

4. HIV/AIDS

5. LOW SPERM COUNT

6. MENOPAUSE DISEASE

7. EPILEPSY

8. ASEPSIS

9. CANCER

10.ANXIETY DEPRESSION

11.PREGNANCY PROBLEM

12.SHORT SIGHTEDNESS PROBLEM

13.ALS

14.PTSD

15.ADHD
Roxas Kimberly
|
February 04, 2019
I'm giving a testimony about DR.MAGGI the great Herbalist, he has the cure to all manner of diseases, he cured my herpes simplex virus, though I went through different website I saw different testimonies about different spell casters and herbalist, I was like: 'Many people's have the herpes simplex virus cure why are people still suffering from it?' I though of it, then I contact DR MAGGI via email, I didn't believe him that much, I just wanted to give him a try, he replied my mail and Needed some Information about me, then I sent them to him, he prepared it (CURE) and sent it to me through Airfreight Online Courier Service for delivery, he gave my details to the Courier Office, they told me that 2-3 days I will receive the parcel and i took the medicine as prescribed by him and I went for check-up 2 week after finishing the medicine, I was tested herpes simplex virus negative, if you are herpes simplex virus patient do me a favor by you contacting him and I assure anyone who is suffering it,your problem will never remain the same again you will be cured.also DR MAGGI help my sister husband to cure his HIV/AIDS he was suffering from it for the past 3 years, After he {cure} my herpes simplex virus, then my sister heard about it, she went home to tell her husband about DR MAGGI then her husband email him and explain his problem to him, he also prepare herbal medicine and he use Airfreight courier service to sent him the herbal medicine and he instruct him on how he will be using it for 14 days, That on the 15 days of it, he should go and check his self in the hospital and he did as he was instructed by DR MAGGI to GOD be the glory he was cure of his HIV/AIDS which he was suffering from for the past 3 years thanks to these great man we will ever remain grateful to you sir indeed might work you did in our families. When you contact him, make sure you tell him that I refer you.. contact him via: Maggiherbalcenter@gmail.com or whats-app his telephone number 1(312)767-3460.or you can also text him on 1(662)967-1783 or you can also view his webs:drmaggiherbalcenter.webs.com.
HOWARD VIVIAN
|
February 03, 2019
I’m here to testify about what DR. MAGGI did for me. I have been suffering from (GENITAL HERPES VIRUS) disease for the past 3 years and had constant pain and inching, especially in my private part. During the first year, I had faith in God that i would be cured someday.This disease started circulating all over my body and I have been taking treatment from my doctor, few weeks ago I came across a testimony of Rose Smith on the internet testifying about a Man called DR. MAGGI on how he cured her from 7 years HSV 2. And she also gave the email address of this man, advise anybody to contact him for help on any kind of diseases that he would be of help, so I emailed him telling him about my (HSV 2) he told me not to worry that I was going to be cured!! Well, I never doubted him I have faith he can cure me too,, DR. MAGGI prepared and sent me Healing Oil, Soap, roots and herbs which I took. In the first one week, I started experiencing changes all over me, after four weeks of using his Roots/ Herbs, Oil and Soap, I was totally cured. no more inching , pain on me anymore as DR. MAGGI assured me. After some time I went to my doctor to do another test behold the result came out negative. So friends my advise is if you have such disease or know anyone who suffers from it or any other disease like HPV, HBV, HIV, ALS, HBP, CANCER etc. you can contact DR. MAGGI for help via email} Maggiherbalcenter@gmail.com or call 1(662) 967-1783 or whatsapp him on 1(312) 767-3460 You can also email me on howardvivian222@gmail.com. I may not reply your mail immediately but at my leisure i will do so, Thanks once again DR. MAGGI for making me a happy woman again. or visit his web:drmaggiherbalcenter.webs.com
james mccall
|
February 02, 2019
HSV NOT THE END OF THE WORLD..

It was like the world was crushing down on me when i was diagnosed of hsv1&2. To me it was the end of the road. it became more frustrating was i began to loose my love, respect from my friends and family members, the virus was very tough but the stigma was much more tougher. I cried out my life all night and day because the virus,, pain and humiliation was too much for me to live with so i planned of taking my life and i tried twice and failed, God use my elder brother to save me because he wanted me to be inspiration to those who think there is nothing left for them to live with. My brother thought me to always thank God in any circumstance and i have live like that until God decided to show me mercy by healing me using the man behind this email: drokougbespecialhome@gmail.com or add him on whatsapp 2348119278442 Dr Okougbe is great. If you happen to be a victim of this frustrating virus, see me as an inspiration. i trusted in God and everything worked out for my good so i expect you to do same. and if you are among those who stigmatize people living with one ailment or the other, it's time to show them love knowing that they were once clean like you and bad situation can befall anybody, so treat them with respect because they are someone's mother, father, sister, brother, husband, wife, e.t.c. Above all, try to stay safe from STDs/ STIs, be careful. thanks
HOWARD VIVIAN
|
February 01, 2019
I’m here to testify about what DR. MAGGI did for me. I have been suffering from (GENITAL HERPES VIRUS) disease for the past 3 years and had constant pain and inching, especially in my private part. During the first year, I had faith in God that i would be cured someday.This disease started circulating all over my body and I have been taking treatment from my doctor, few weeks ago I came across a testimony of Rose Smith on the internet testifying about a Man called DR. MAGGI on how he cured her from 7 years HSV 2. And she also gave the email address of this man, advise anybody to contact him for help on any kind of diseases that he would be of help, so I emailed him telling him about my (HSV 2) he told me not to worry that I was going to be cured!! Well, I never doubted him I have faith he can cure me too,, DR. MAGGI prepared and sent me Healing Oil, Soap, roots and herbs which I took. In the first one week, I started experiencing changes all over me, after four weeks of using his Roots/ Herbs, Oil and Soap, I was totally cured. no more inching , pain on me anymore as DR. MAGGI assured me. After some time I went to my doctor to do another test behold the result came out negative. So friends my advise is if you have such disease or know anyone who suffers from it or any other disease like HPV, HBV, HIV, ALS, HBP, CANCER etc. you can contact DR. MAGGI for help via email} Maggiherbalcenter@gmail.com or call 1(662) 967-1783 or whatsapp him on 1(312) 767-3460 You can also email me on howardvivian222@gmail.com. I may not reply your mail immediately but at my leisure i will do so, Thanks once again DR. MAGGI for making me a happy woman again. or visit his web:drmaggiherbalcenter.webs.com
Karen Smith
|
January 30, 2019
I Never believed i was ever going to be HSV2 Negative again, Dr. Okoni has given me reasons to be happy, i was HSV2 positive for 2 years and all the means i tried for treatment was not helpful to me, but when i came on the Internet i saw great testimony about Dr Okoni on how he was able to cure someone from HIV, this person said great things about this man, and advice, i decided to give him a try, he requested for my information which i sent to him, and he told me he was going to prepare for me a healing portion, which he wanted me to take for 7 days, and after which i should go back to the hospital for check up, well after taking all the treatment sent to me, i went back to the Hospital for check up, and now i have been confirmed HSV2 Negative, friends if you have anything kind of disease contact Dr Okoni on any treatment for any Disease he is the one only i can show you all up to reach him on: okoniherbalsolution@outlook.com and Website:okoniherbalsolution.webs.com, you can also getting in touch with him on call or WhatsApp 2348146495245.
Karen Smith
|
January 30, 2019
I Never believed i was ever going to be HSV2 Negative again, Dr. Okoni has given me reasons to be happy, i was HSV2 positive for 2 years and all the means i tried for treatment was not helpful to me, but when i came on the Internet i saw great testimony about Dr Okoni on how he was able to cure someone from HIV, this person said great things about this man, and advice, i decided to give him a try, he requested for my information which i sent to him, and he told me he was going to prepare for me a healing portion, which he wanted me to take for 7 days, and after which i should go back to the hospital for check up, well after taking all the treatment sent to me, i went back to the Hospital for check up, and now i have been confirmed HSV2 Negative, friends if you have anything kind of disease contact Dr Okoni on any treatment for any Disease he is the one only i can show you all up to reach him on: okoniherbalsolution@outlook.com and Website:okoniherbalsolution.webs.com, you can also getting in touch with him on call or WhatsApp 2348146495245.
jessica ana
|
January 30, 2019
Am here to appreciate Dr Aba for using his herbal medicine to cure my Herpes virus. since 3 years now I have been living with this virus and it has been giving me challenges, I was so perplexed cause i have been taking several drugs to be cured but all of my effort was in vain,one morning i was browsing through the internet then i saw several testimonies about Dr. Aba curing people from Herpes virus and immediately i contacted Dr. Aba on his email: dr.abaherbalhome@gmail.com, i told him about my troubles and he told me that i must be cured, gave me some instructions and which i rightly followed. so he prepared a herbal medicine for me and sent it to me which i used for 2 weeks and everything was like a dream to me and my Herpes virus was totally gone, why don't you contact him today and be free from your diseases because he is very good and honest Doctor. contact him via email; dr.abaherbalhome@gmail.com or whatsApp him on 2348107155060
Elizabeth Matheus
|
January 30, 2019
HELLO EVERYONE.. FEW MUNINETS TO REDY THIS INFOR ON HERPES CURE 2018..

2017 MY MOTHER WAS DIAGNOSED OF HERPES/ KNOWN AS GENITAL WARTS ,I SPENT A LOT OF MONEY ON HER MEDICATION TILL A POINT I EVEN LOST HOPE,BECAUSE MY MOTHER WAS GRADUALLY DYING AND LOST HER MEMORY TOO, I WAS SO DESPERATE TO GET MY MOTHER BACK TO NORMAL, ONE DAY MY UNCLE WHO LIVES IN LONDON UNITED KINGDOM TOLD ME ABOUT DR OLIHA ,WHO HELPED HIM GET RID OF HERPES /GENITAL WART WITH HERBAL MEDICINE AND HIS HERBAL SOAP ,I WAS SO SHOCKED WHEN HE TOLD ME ABOUT THIS ,ALTHOUGH I NEVER BELIEVE IN HERB BUT, I KEEP TO BELIEVE BECAUSE MY UNCLE CAN'T TELL ME LIES WHEN IT COMES TO HEALTH CONDITION I CONTACTED DR OLIHA VIA HIS EMAIL; OLIHA.MIRACLEMEDICINE@GMAIL.COM , YOU CAN TALK TO HIM VIA CALL OR WHATSAPP MESSENGER ON 2349038382931 , HE REPLIED AND ASK ME TO SEND MY HOME ADDRESS AND MY MOTHER'S DETAIL AND THEN I PURCHASED THE HERBAL MEDICINE,SENT ME THE HERBAL MEDICINE THROUGH COURIER SERVICE, WHEN I RECEIVED THIS HERBAL MEDICINE USED IT FOR 2 WEEKS, AND 4 DAYS OF USAGE THE WARTS FELL OFF, MY MOTHER I NOW TOTALLY CURED AND MY MOTHER IS LIVING FREE AND HAPPY AGAIN. YOU CAN TALK TO DR VIA HIS MOBILE NUMBER OR WHATS APP HIM ON 2349038382931.ALL THANKS TO DOCTOR DR OLIHA
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