Researches at UCSD Health Sciences identify gene with functional role in aging of eye
Published - 02/04/20 - 09:00 AM | 6119 views | 431 431 comments | 26 26 recommendations | email to a friend | print

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published online Jan. 14, 2020 in the journal Aging Cell, researchers at the University of California San Diego School of Medicine say the gene appears to play a key role in age-associated functional and anatomical aging in vivo in mouse retinas, a finding that has direct relevance to age-related eye diseases. 

Specifically, the research team, led by senior author Dorota Skowronska-Krawczyk, Ph.D., assistant professor in the Viterbi Family Department of Ophthalmology at UC San Diego Shiley Eye Institute, found that an age-related decrease in ELOVL2 gene expression was associated with increased DNA methylation of its promoter. Methylation is a simple biochemical process in which groups of carbon and hydrogen atoms are transferred from one substance to another. In the case of DNA, methylation of regulatory regions negatively impacts the expression of the gene. 

When researchers reversed hypermethylation in vivo, they boosted EVOVL2 expression and rescued age-related decline in visual function in mice. “These findings indicate that ELOVL2 actively regulates aging in mouse retina, provides a molecular link between polyunsaturated fatty acids elongation and visual functions, and suggests novel therapeutic strategies for treatment of age-related eye diseases,” wrote the authors.

ELOVL2 is involved in production of long-chain omega-3 and omega-6 polyunsaturated fatty acids, which are used in several crucial biological functions, such as energy production, inflammation response and maintenance of cell membrane integrity. The gene is found in humans as well as mice. 

In particular, ELOVL2 regulates levels of docosahexaenoic acid or DHA, a polyunsaturated omega-3 fatty acid abundantly found in the brain and retina. DHA is associated with a number of beneficial effects. Notably, its presence in photoreceptors in eyes promotes healthy retinal function, protects against damage from bright light or oxidative stress and has been linked to improving a variety of vision conditions, from age-related macular (AMD) degeneration to diabetic eye disease and dry eyes. 

Skowronska-Krawczyk said the work demonstrated for the first time that a “methylation clock” gene had a functional role in the aging of an organ. In this case, the eye. DNA methylation is used throughout the human body, essentially turning biological switches on and off to maximize efficient operation. It has key regulatory roles in the body’s cardiovascular, neurological, reproductive and detoxification systems. 

In recent years, there has been much work and progress in identifying possible biomarkers that predict the biological age (not chronological) of individuals. Such biomarkers would be useful in identifying risk and status of age-related diseases. ELOVL2 is among the genes attracting greatest interest.  

“I have been asked whether I think ELOVL2 is the aging gene,” said Skowronska-Krawczyk. “After thinking about it, it is not unreasonable to think that lower ELOVL2 expression might be at the basis for many age-related conditions. Future work in our lab will address that question.” 

For the full study, visit https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13100

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statonaaaaaaaa
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9 Hours Ago
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10 Hours Ago
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12 Hours Ago
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17 Hours Ago
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18 Hours Ago
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19 Hours Ago
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Amanda Bella
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17 Hours Ago
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laurie perez
|
20 Hours Ago
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|
June 02, 2020
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Amanda Bella
|
17 Hours Ago
I Want To Appreciate Dr.OYAGU for his great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And i Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have The Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguherbalhome@gmail.com

Or Cell Whatsapp Number 2348101755322 thank you
roma eva
|
June 02, 2020
Human PapilomaVirus (HPV) Cure Found By Dr Sayo If you're wondering why am here or why am doing this!, i just want to show appreciation to God, and i want other persons who is suffering from this deadly illness, ( Herpes, Coronary Artery Disease (Ischemic Heart Disease), Hiv/AID, Stroke, Trachea, Bronchus, and Lung Cancers, Diarrhea Diseases, Diabetes Mellitus, Dengue, Rota-virus, Other STD and others ) maybe because of ignorance. if you see this don't ignore, i was a victim of hpv, some one introduced him to me, i wrote him, told him what i was going through,  i was not too sure he could help, because i seen other persons, or post but no good outcome, he told me he could help, like others, i got the medicine or the herb whatever you may want to call it, he didn't even charge me a lot, to God i didn't want to use it, but i did, to God be the glory am the one sending this post today in good health and sound mind, ..smile.. i seek for him, i didn't mind the distance so i could show appreciation, i meet with Dr Sayo he didn't ask for anything, all he said is, 'It's God doing. I saw him treat people with different situation and problem maybe worse than yours, tell others. so am telling you today, don't ignore this, if you see this post, tell the next person who you think might need this. contact him,on email (sayoherbalhealer@gmail.com)
anonymous
|
June 02, 2020
I Want To Appreciate Dr.OYAGU for his great deeds, I Was Diagnosed With type 2 Herpes Virus Last year,And i Was Looking For Solution To Be Cured Luckily I Saw Testimonies On How Dr.OYAGU Cure Herpes Virus I Decided To Contact Dr.OYAGU I Contacted Him He Prepared A Herbal Medicine Portion And Sent It To Me,I Started The Herbal Medicine For My Health.He Gave Me Step By Step Instructions On How To Apply It, When I Applied It As Instructed, I Was Cured Of This Deadly Herpes Within 2 weeks, I Am Now Herpes Negative.My Brother And Sister I No That There Are So Many People That Have The Same Herpes Virus Please contact Dr OYAGU To Help You Too,And Help Me To Thank Dr.OYAGU For Cure Me, I’m Cured By Dr. OYAGU Herbal Medicine,His Contact Email:oyaguherbalhome@gmail.com

Or Cell Whatsapp Number 2348101755322 thank you
anonymous
|
June 02, 2020
Herpes Cure Testimony,

I was diagnose with Genital Herpes for the past 2 years and I have been searching for cure. I have several outbreaks on my back and it really affected me morally, I read a testimony on this platform of a lady from Nevada who was cured from Herpes with Dr Nelson Herbal medicine including the doctor official email address. I contacted the doctor through his email, after much discussion and few questions he prepared the Herbal medicine and asked for my address which I received the Herbal medicine 3 days later and with his prescription I drank the Herbal medicine for 21 days. After concluding the herbal medicine I went for test and my IgG result was confirmed Negative with no trace of the virus on my blood. Contact Dr Nelson and be cured his email; 

drnelsonsaliu10@gmail.com or whatsapp text  23480111067336

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Robert Jennifer
|
June 02, 2020
When i first heard about herbal remedy i never believe on such word until i found Dr Ajayi a great traditional doctor that was introduced to me by a friend that suffered from Herpes virus  and was cure with the help of this great herbal doctor Dr Ajayi so i decided to contact him for help in getting rid of my families genital herpes virus  which i did and all i was told to provide was just some materials use in preparation of the natural cure and that i did and now i am the happiest person on earth because i am writing this testimony of mine with joy and happiness in my heart to the whole world to know that natural remedy is real because i am a living testimony of Dr Ajayi and i want you all to contact Dr Ajayi for your healing via his email: ajayiherbalhome@gmail.com you can also call or whatsapp him 2348154724883  thanks once again Dr Ajayi for your healing...
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