UC San Diego Health Sciences study finds how marijuana accelerates HPV-related head and neck cancer
Published - 01/22/20 - 09:00 AM | 3860 views | 33 33 comments | 20 20 recommendations | email to a friend | print

University of California San Diego School of Medicine researchers have identified the molecular mechanism activated by the presence of tetrahydrocannabinol (THC) — the ingredient that causes people to feel the euphoria or “high” associated with cannabis — in the bloodstream that accelerates cancer growth in patients with human papillomavirus (HPV)-positive head and neck squamous cell carcinoma.

“HPV-related head and neck cancer is one of the fastest-growing cancers in the United States. While at the same time, exposure to marijuana is accelerating. This is a huge public health problem,” said Joseph A. Califano III, MD, senior author and professor and vice chief of the Division of Otolaryngology in the Department of Surgery at UC San Diego School of Medicine.

Head and neck squamous cell carcinoma is the sixth most common cancer worldwide. These cancers begin in the cells that line the mucous membranes inside the mouth, nose, and throat. Approximately 30 percent of cases of this disease are related to HPV infection, and it is these cases, in particular, that are on the rise. Califano suggested increased marijuana use may be a driving factor. 

Previous studies have linked daily marijuana exposure to an increased prevalence of HPV-related throat cancer. However, a mechanism linking cannabis exposure to increased growth of the cancer was unknown. 

Reporting in the Jan. 13, 2020 online edition of Clinical Cancer Research, a journal of the American Association for Cancer Research, researchers outline how the presence of THC in the bloodstream activates the p38 MAPK pathway, which controls programmed cell death called apoptosis. When activated, p38 MAPK prevents apoptosis from occurring, thus allowing cancer cells to grow uncontrollably.

Working with Chao Liu, MD, visiting scientist at UC San Diego and a physician at China’s Central South University, and other colleagues, Califano and team used animal and human cell lines to show that THC turns p38 MAPK on and were able to stop the growth of HPV-positive head and neck cancer by turning off the pathway.  

The team then analyzed blood samples from patients with HPV-related throat cancer who had their genomes comprehensively mapped to define activated gene pathways. Similar to the cell lines, the blood samples showed p38 MAPK activation and loss of apoptosis in tumors from patients with THC in their blood.

The authors said studies and public opinion suggestions that THC and other cannabis products have cancer-fighting properties need additional, more critical evaluation. Past studies showing anti-cancer effects of THC and other cannabinoids often used levels of THC higher than those found with recreational use, but doses used recreationally clearly activate a cancer-causing pathway said Califano.

“We now have convincing scientific evidence that daily marijuana use can drive tumor growth in HPV-related head and neck cancer,” said Califano. “Marijuana and other cannabis products are often considered benign, but it is important to note that all drugs that have benefits can also have drawbacks. This is a cautionary tale.”

According to the Centers for Disease Control and Prevention (CDC), HPV infections are responsible for approximately 35,000 new cancer diagnoses each year in the United States. Infection is so common that nearly all men and women will get at least one type of HPV at some point in their lives. Most clear up on their own, without the person ever knowing they’ve had it.

Several vaccines are available that can prevent the majority of HPV-related cancers. The vaccines work best when they are given before a person is exposed to the virus. The CDC recommends vaccinating boys and girls age 11 to 12 years old but it can be administered as early as age 9.

According to the National Institute on Drug Abuse, 15 percent of youth 12 to 17 years old and 47% of adults age 26 and older have used or tried marijuana.

Together, a low HPV vaccination rate and an increase in marijuana use among youth has the makings of a storm, said Califano, physician-in-chief and director of the Head and Neck Cancer Center at Moores Cancer Center at UC San Diego Health. 

Moores Cancer Center is one of only 51 National Cancer Institute-designated Comprehensive Cancer Centers in the country and the only such center in San Diego County.

Treatment options for patients with early- or late-stage head and neck cancers include minimally invasive surgery, reconstruction and rehabilitation, proton therapy and other radiation therapy, innovative clinical trials and targeted therapy, including immunotherapy. 

The Head and Neck Cancer Center provides comprehensive care that includes counseling, education and support groups, nutrition, dental rehabilitation, speech and language therapy, and social workers to help patients through every step of the process beginning with diagnosis to support lifelong wellness. 

Califano and team are now looking at whether cannabidiol, or CBD, has a similar effect to THC. CBD is another major chemical compound found in marijuana, but does not produce the “high” and is now commonly used in various over-the-counter products, such as lotions, ointments, and edibles.

In addition, the team is investigating whether p38 MAPK can be targeted with drugs to stop HPV-related head and neck cancer from growing.

Co-authors include: Chao Liu, Sayed Sadat, Koji Ebisumoto, Akihiro Sakai, Bharat Panuganti, Shuling Ren, Yusuke Goto, Sunny Haft, Takahito Fukusumi, Mizuo Ando, Yuki Saito, Pablo Tamayo, Huwate Yeerna, William Kim, Jacqueline Hubbard, Andrew Sharabi and J. Silvio Gutkind from UC San Diego; and Theresa Guo from Johns Hopkins Medical Institutions.

Funding for this research came, in part, from the National Institute of Dental and Craniofacial Research and National Institute of Health (R01 DE023347, U01CA217885, R01HG009285, R01CA121941 and P30CA023100).

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Andy baldwin
|
18 Hours Ago
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STEVEN YOUNG
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March 26, 2020
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Alfonso Navia
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20 Hours Ago
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aianjosh
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March 22, 2020
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March 21, 2020
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Navia
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March 21, 2020
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Frank willus
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March 15, 2020
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Jan Wong
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March 15, 2020
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MiracleSpellHome@yah
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March 15, 2020
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March 12, 2020
I have be living with  herpes for over 4 years now and it has be a big problem to me. One day i came across a woman testimony on forum saying she get cured of her Herpes with the help of Dr Ajayi herbal medicine at first i did not believe i was doubting because my doctor told me they is no cure for this disease,so i contacted him with the email the lady drop and write to him about my problems the he told me not to worry that am in the right place he told me what to do to get cured so i really did it few month later i went to the doctor and do a test and discover that am totally cured of my  herpes then i wrote to him and thank him for curing me please are you out there I advice you to contact the great doctor know as Dr Ajayi i promise to always share what you did for me contact him via email ajayiherbalhome@gmail.com You can also call Or whatsAPP him on 2348154724883...
Donald Gary
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March 11, 2020
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Dansi
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March 11, 2020
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young03
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March 11, 2020
My Name is Young i live in Germany, I have not seen anything that is so perfect like Dr,Tony spell, Am writing this article to thank Dr,Tony the powerful spell caster that help me recently to bring back my ex lover that left me for another woman for no reason for the past 8 years. After seeing a post on the internet by Kate Adams from USA saying how she was helped by Dr Tony, i also decided to contact him for help because i had no choice all i wanted was for me to get my lover back and happiness.To my greatest surprise my lover came home on his knees that i should find a place in my heart to forgive him,i was truly astonished and shocked when my lover knelt down begging for forgiveness and for me to accept him back.. I am really short of expressions, and i don't know how much to convey my appreciation to you Dr, Tony you are a God sent to restore broken relationship, And now i am a joyful woman, Dr,Tony is the answer to all problem. his contact details are Tonylovespell@aol.com Cell phone number 1(903) 847 0267 Whatsapp  1(667-239-1002.
Brayn
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March 11, 2020
Hello, I want to write a little review about the good work of doctor Solution who cured me from HSV 1 and 2 for just 2 week with his herbal medicine, I never believe I can be normal again and have a good life like others I always regretted the day I got diagnose with the virus, I was lost of hope when my doctor told me there is no cure for it but I keep thinking and thinking about my future, if I can have kids of my own well I am so grateful for my helper who get me cured with his herbal medicine, I went online in search of anything that can help me because I can’t deal with it forever so I found this doc solution email on a blog of someone who was cured by him I quickly contacted him for help and explained all my pain to him, he told me not to worry about it there is cure for real, I never believe until he sent me the herbal medicine when I ordered for it and I got it within 5 working days that is how I took the medicine for 2 weeks and the following week I went for test just to confirm I was 100% cured from this sickness what a miracle in my life I am so happy right now, you can also get in contact with him if you have such sickness through email address:: solutionhealinghome@gmail. com
Wilfrey
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March 11, 2020
Am wilfrey by name, i was diagnosed with Herpes for 6years ago i lived in pain with the knowledge that i wasn't going to ever be well again i contacted so many herbal doctors on this issue and wasted a large sum of money but my condition never got better i was determined to get my life back so one day i saw mr deshant post on how Dr Iyoha saved him from the VIRUS with his herbal medicine i contacted Dr Iyoha on his email address driyohasolutiontemple@yahoo.com we spoke on the issue i told him all that i went through and he told me not to worry that everything will be fine again so he prepared the medicine and send it to me through courier service and told me how to use it, after 2 weeks of usage I went to see the doctor for test ,then the result was negative,am the happiest woman on earth now. this testimony is real.thanks to Dr Iyoha God bless you. you can also reach him on his number: 1 407 337 9869

Dr Iyoha also cure the following

1 cancer cure

2 diabetes cure

3 ringing ear

4 herpes cure

5 warts cure

6 HPV cure

7 HIV

8 get your ex back

9 pregnancy herbal medicine

10 prostate enlargement

11 Hepatitis B

Alley erica
|
March 07, 2020
I'm Alley by name, i was diagnosed with Herpes virus for 3 years, i lived in pain with the knowledge that i wasn't going to ever be well again i contacted so many herbal doctors on this issue and wasted a large sum of money but my condition never got better i was determined to get my life back so one day i saw Mr Brown post on how Dr Azu saved him from the VIRUS with herbal medicine i contacted Dr Azu on his email address dr.azuherbalhome@gmail.com we spoke on the issue i told him all that i went through and he told me not to worry that everything will be fine again so he prepared the medicine and send it to me through courier service and told me how to use it,after 14 days of usage I went to see the doctor for test ,then the result was negative,am the happiest woman on earth now. this testimony is real.thanks to Dr Azu God bless you. you can also reach him on his whatsApp number 2347087313747
ibrahim patricia
|
February 28, 2020
I never believed i would be healed someday.This disease started circulate all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HSV 2 and Cancer) by this Man Dr Okougbe and she also gave the email address of this man and advise we should contact him for any sickness that he would be of help, so i wrote to drokougbespecialhome@gmail.com telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the Doctor Okougbe assured me that i have cured,after some time i went to my Dr to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email drokougbespecialhome@gmail.com or : call whatsapp 2348119278442
Robert kaith
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February 27, 2020
LOVE SPELL CASTER (DR. GBOJIE) THAT HELPED ME BRING BACK MY DIVORCE HUSBAND CONTACT HIM NOW FOR ANY KIND OF HELP

With so much in my heart i am here to express myself on how Dr. GBOJIE saved my marriage from divorce. Myself and my husband were having some misunderstanding and it was tearing our marriage apart to the extend my husband was seeking for a divorce. So i have no option than to go to the internet to seek for solution to my problem it was there i came across Dr. GBOJIE details and about how he has helped a lot of people by restoring there relationship. I contact Dr. GBOJIE and in less than 48 hours my husband cancelled the divorce papers. Now myself and my husband live together in peace and harmony all thanks to Dr .GBOJIE for saving my marriage from breaking up. Dr. GBOJIE contact information are via email: gbojiespiritualtemple@yahoo.com , gbojiespiritualtemple@gmail.com or call his phone number or WhatsApp: 2349066410185 .or check out his website :http://gbojiespiritualtemple.website2.me  
Anthony Mark
|
February 27, 2020
Cure for Herpes Virus

Its a great pleasure for me to write this testimony about how I got my Genital Herpes cured within a month. I have been reading so many comments of some people who were cured from various diseases by Dr Ahmed Usman herbal medicine but I never believed them. I was hurt and depressed so I was too curious and wanted to try DR. Ahmed then i contacted him through his email, he assured me 100% that he will cure me, I pleaded with him to help me out. My experience with him was great. He sent me his herbal medicine and prescribed the usage of the herbal medicine. He asked me to go for a medical check up after two weeks of usage. I agreed with him I took this herbal medicine as instructed by him and went for a check up, to my greatest surprise my result was negative, I am really happy that I am cured and healthy again. I have waited for a month to be very sure I was completely cured before writing this testimony. I did another blood test one week ago and it was still Herpes negative, with no trace of the virus on my blood so I guess its time I recommend him to anyone suffering from Herpes Virus. contact Dr. Ahmed through his official email address: drahmedusman5104@gmail.com  

He has herbal cure for Diabetes, Hepatitis, Cancer, Heart diseases and Liver diseases. 
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