Researches at UCSD Health Sciences identify gene with functional role in aging of eye
Published - 02/04/20 - 09:00 AM | 7874 views | 488 488 comments | 27 27 recommendations | email to a friend | print

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published online Jan. 14, 2020 in the journal Aging Cell, researchers at the University of California San Diego School of Medicine say the gene appears to play a key role in age-associated functional and anatomical aging in vivo in mouse retinas, a finding that has direct relevance to age-related eye diseases. 

Specifically, the research team, led by senior author Dorota Skowronska-Krawczyk, Ph.D., assistant professor in the Viterbi Family Department of Ophthalmology at UC San Diego Shiley Eye Institute, found that an age-related decrease in ELOVL2 gene expression was associated with increased DNA methylation of its promoter. Methylation is a simple biochemical process in which groups of carbon and hydrogen atoms are transferred from one substance to another. In the case of DNA, methylation of regulatory regions negatively impacts the expression of the gene. 

When researchers reversed hypermethylation in vivo, they boosted EVOVL2 expression and rescued age-related decline in visual function in mice. “These findings indicate that ELOVL2 actively regulates aging in mouse retina, provides a molecular link between polyunsaturated fatty acids elongation and visual functions, and suggests novel therapeutic strategies for treatment of age-related eye diseases,” wrote the authors.

ELOVL2 is involved in production of long-chain omega-3 and omega-6 polyunsaturated fatty acids, which are used in several crucial biological functions, such as energy production, inflammation response and maintenance of cell membrane integrity. The gene is found in humans as well as mice. 

In particular, ELOVL2 regulates levels of docosahexaenoic acid or DHA, a polyunsaturated omega-3 fatty acid abundantly found in the brain and retina. DHA is associated with a number of beneficial effects. Notably, its presence in photoreceptors in eyes promotes healthy retinal function, protects against damage from bright light or oxidative stress and has been linked to improving a variety of vision conditions, from age-related macular (AMD) degeneration to diabetic eye disease and dry eyes. 

Skowronska-Krawczyk said the work demonstrated for the first time that a “methylation clock” gene had a functional role in the aging of an organ. In this case, the eye. DNA methylation is used throughout the human body, essentially turning biological switches on and off to maximize efficient operation. It has key regulatory roles in the body’s cardiovascular, neurological, reproductive and detoxification systems. 

In recent years, there has been much work and progress in identifying possible biomarkers that predict the biological age (not chronological) of individuals. Such biomarkers would be useful in identifying risk and status of age-related diseases. ELOVL2 is among the genes attracting greatest interest.  

“I have been asked whether I think ELOVL2 is the aging gene,” said Skowronska-Krawczyk. “After thinking about it, it is not unreasonable to think that lower ELOVL2 expression might be at the basis for many age-related conditions. Future work in our lab will address that question.” 

For the full study, visit https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13100

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joyce lucky
|
June 12, 2020
I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past one years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr patrick and she also gave the email address: dr.patrickherbalhome@gmail.com of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. patrick telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the doctor assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email:: dr.patrickherbalhome@mail.com or whatsApp his number on 2348055367947  
Meghan Kirsty
|
June 23, 2020


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jessica martin
|
June 12, 2020
I’m so happy to testify of the good work of Dr. patrick I Suffer from Herpes virus since 2007 and i had frequent symptoms in my private area, after some time it will go away after using acyclovir drugs, then come back after some months. it was disheartening since i have been diagnosed, but after finding Dr. patrick and his reviews i was convinced that he will definitely cure me and so i contacted and he told me how to get his medicine and using it for just 14 days and i will go and check up and first i said how can that be possible but i used his herbal medicine after making purchase and truly i used it and went for the test again, and my result came back negative. so i made it a task to share this good testimony in the internet so that those sick can benefit and get cured. What app or call: 2348055367947 Email:dr. patrickherbalhome@gmail.com

joyce lucky
|
June 12, 2020
I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past one years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr patrick and she also gave the email address: dr.patrickherbalhome@gmail.com of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. patrick telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the doctor assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email:: dr.patrickherbalhome@mail.com or whatsApp his number on 2348055367947  
javion mason
|
June 12, 2020
I have be suffered from (HSV 2) for 2 years, I was given some tablets at the hospital but I refused to take it, They said I have to be on it for life so I don't want to take a drugs everyday for life. No point in taking medicine everyday when u won't get cure from it and I was advice to seek for natural herbal cure, after some time I found dr Aba, he"s the most trustful herbalist that have herbs to cure wicked symptom's, I emailed dr Aba, for 2 weeks been his patient he cured my (HSV 2) with his herbal medicine. I only used his natural herbs for two weeks it was 100% cure. I'm not (HSV 2) patient anymore. I'm happy i finally got cured out of this mess been in my body for 2 years. I also recommend you if you're living with herpes virus i also want you to be free contact dr Aba with his email attach to my post. dr.abaherbalhome@gmail.com or you can call or whats-app his cell phone number on  2348107155060  
Meghan Kirsty
|
June 20, 2020
Hello everyone. Lord Masuka has a good remedy for herpes Virus , I was a carrier of herpes virus for 6 years until a colleague of mine told me about how Lord Masuka cured him of HIV, so I contacted him, he assured me that i will be cured, and he also told me what is needed to prepare the medicine, immediately i arranged for the ingredients he prepared the remedy and send it to me with instruction on how to take it for 2 weeks and that after the period of 2 weeks i should go for a check up and getting to the hospital i was confirmed HSV 2 Negative. All thanks to Lord Masuka for making me whole again, everything is fine, If there is any of you with same problem or you out there living with HIV aids contact him today for your healing, he is extraordinary, he can cure any disease. Below are his contact information or you can also visit his website for more info.

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rose8289398
|
June 12, 2020
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jasmie moore
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June 11, 2020
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jasmie moore
|
June 11, 2020
hello everyone, if you are surfery for herpes virus i advice you contact dr aziza for cure,I suffer for hsv 2 for four years and six months before i came in contact with this doctor, he prepared herbal medicine and sent to me via DHL delievery service to my country and guided me on how to use it. after using his herbs as priscribed for 3 weeks my four years herpes was cured. you can as well take a bold step asap curing yours via whatsapp 2348052498003 or drazizahome4cure@gmail.com
Angelina Robert
|
June 11, 2020
Dr. UGANLOGA has really made me so much believe in him by getting me cured with his herbal treatment. i really appreciate you Dr UGANLOGA for bringing back happiness to my life. thanks you so much,friends join me to thank him for what he has done for me.Email: druganlogaherbahome@gmail.com you can call or whatsapp number: 2348107181623

hello everyone here I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past 3 years and i have had constant pain, sickness. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from the hospital also i have use some herbal medicine from African but non could cure this disease from me. but on one faithful day i came across a testimony of MARGRET HUNTER testifying on how DR UGANLOGA CURED HER of her 6 YEARS herpes disease so i wrote Dr.UGANLOGA on his EMAIL. telling him about my (HERPES Virus) well after all the procedures and remedy given to me by DR UGANLOGA, one week later i started experiencing changes all over body. and when it was two weeks of using his herbal medicine,i went to the hospital and it was confirmed that I am now free from the disease and i cannot thank DR UGANLOGA enough that is i am here to testify that i am not longer a herpes patient, I have experience a total transformation in my whole life,for all herpes patients get your herbal medicine to cure your sickness. And there has being rapid improvement in my health, I no longer feel pains and I wake up each morning feeling revived. So friends my advise is if you have such sickness or any other at all,you can contact him.Email: druganlogaherbalhome@gmail.com or you can call or whatsapp number: 2348107181623 He can also do the following CANCEREPILEPSYPENIS ENLARGEMENT BREAST ENLARGEMENT BUM ENLARGEMENT

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Meghan Kirsty
|
June 23, 2020


Hello everyone. Lord Masuka has a good remedy for herpes Virus , I was a carrier of herpes virus for 6 years until a colleague of mine told me about how Lord Masuka cured him of HIV, so I contacted him, he assured me that i will be cured, and he also told me what is needed to prepare the medicine, immediately i arranged for the ingredients he prepared the remedy and send it to me with instruction on how to take it for 2 weeks and that after the period of 2 weeks i should go for a check up and getting to the hospital i was confirmed HSV 2 Negative. All thanks to Lord Masuka for making me whole again, everything is fine, If there is any of you with same problem or you out there living with HIV aids contact him today for your healing, he is extraordinary, he can cure any disease. Below are his contact information or you can also visit his website for more info.

Email: Lordmasukaspelltemple@hotmail.com

Website: https://lordmasukaspelltem3.wixsite.com/masuka?

Whatsapp: 1(234)-307-0752
Christopher morgan
|
June 11, 2020
I have been suffering from Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr.Alli on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr.Alli today on this Email address: Allispellhelp1@gmail.com or WhatsApp him on this Tell.Number 2348100772528.
jessica martin
|
June 10, 2020
I’m so happy to testify of the good work of Dr. patrick I Suffer from Herpes virus since 2007 and i had frequent symptoms in my private area, after some time it will go away after using acyclovir drugs, then come back after some months. it was disheartening since i have been diagnosed, but after finding Dr. patrick and his reviews i was convinced that he will definitely cure me and so i contacted and he told me how to get his medicine and using it for just 14 days and i will go and check up and first i said how can that be possible but i used his herbal medicine after making purchase and truly i used it and went for the test again, and my result came back negative. so i made it a task to share this good testimony in the internet so that those sick can benefit and get cured. What app or call: 2348055367947  Email:dr. patrickherbalhome@gmail.com  
Matt Simerson
|
July 04, 2020
Am Matt Simerson by name, i was diagnosed with Herpes for 5years, i tried so many medications and prescriptions given by my doctors but all to no avail and my condition never got better i was determined to get my life back so one day i saw post on how Lord Masuka cured Stefani of this herpes virus that is eating me up daily with his herbal medicine so i contacted him immediately we spoke on the issue i told him all that i went through and he assured me not to worry that everything will be fine again so he prepared the medicine and send it to me through courier service with the prescription on how to take the medicine daily for 2 weeks, after 14 days of usage I went to see my doctor for test, the result was negative. I'm so overwhelmed with joy, i almost gave up but now i'm healthy and sound all thanks to Lord Masuka for your good works may Allah reward you bountifully. Contact him via his personal email for help Lordmasukaspelltemple@hotmail.com or you can visit his website for more info https://lordmasukaspelltem3.wixsite.com/masuka? You can also reach him on whatsaap 1(234)-307-0752

wanda davis
|
June 10, 2020
Its a great pleasure for me to write this testimony about how i got my Genital Herpes cured a month ago. i have been reading so many comments of some people who were cured from various diseases by Dr Aza but i never believed them. I was hurt and depressed so I was too curious and wanted to try DR. Aza then i contacted him through his email, he assured me 100% that he will heal me, i pleaded with him to help me out. My experience with him was great, he healed me just as he promised. he sent me his medication and ask me to go for a medical check up after two weeks of usage. i agreed with him i took this medication and went for a check up, to my greatest surprise my result was negative, i am really happy that i am cured and healthy again. I have waited for 3weeks to be very sure i was completely healed before writing this testimony. I did another blood test one week ago and it was still Herpes negative. so i guess its time i recommend anyone going through the same way. reach him through his email address: drazaherbalcenter@gmail.com  OR call, add him on Whatsapp  1(315) 795 1518      
mary frankly
|
June 10, 2020
Herpes Cure Testimony,I was diagnose with Genital Herpes for the past 2 years and I have been searching for cure. I have several outbreaks on my back and it really affected me morally, I read a testimony on this platform of a lady from Nevada who was cured from Herpes with Dr Nelson Herbal medicine including the doctor official email address. I contacted the doctor through his email, after much discussion and few questions he prepared the Herbal medicine and asked for my address which I received the Herbal medicine 3 days later and with his prescription I drank the Herbal medicine for 21 days. After concluding the herbal medicine I went for test and my IgG result was confirmed Negative with no trace of the virus on my blood. Contact Dr Nelson and be cured his email; 

drahmedusman5104@gmail.com or whatsapp text  23480111067336

He has Herbal cure for Diabetes, Hepatitis, Heart diseases.

Hypertension, Strokes and Liver diseases.  
joyce lucky
|
June 09, 2020
I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past one years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr patrick and she also gave the email address: dr.patrickherbalhome@gmail.com of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. patrick telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the doctor assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email:: dr.patrickherbalhome@mail.com or whatsApp his number on 2348055367947  
jessica martin
|
June 09, 2020
I’m so happy to testify of the good work of Dr. patrick I Suffer from Herpes virus since 2007 and i had frequent symptoms in my private area, after some time it will go away after using acyclovir drugs, then come back after some months. it was disheartening since i have been diagnosed, but after finding Dr. patrick and his reviews i was convinced that he will definitely cure me and so i contacted and he told me how to get his medicine and using it for just 14 days and i will go and check up and first i said how can that be possible but i used his herbal medicine after making purchase and truly i used it and went for the test again, and my result came back negative. so i made it a task to share this good testimony in the internet so that those sick can benefit and get cured. What app or call: 2348055367947  Email:dr. patrickherbalhome@gmail.com  
karen kennedy
|
June 09, 2020
I'm here to testify about the great work Dr Aza did for me. I have been suffering from (HERPES) disease for the past 5 years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came across a testimony of one lady on the internet testifying about a Man called Dr Aza on how he cured her from Herpes Simplex Virus. And she also gave the email address of this man and advise anybody to contact him for help for any kind of sickness that he would be of help, so I emailed him telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! Well i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as Dr Aza assured me that i will be cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can contact Dr Aza via email drazaherbalcenter@gmail.com You can also call or whatsApp his telephone number on 13157951518. Thanks once again Dr Aza.    
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