Researches at UCSD Health Sciences identify gene with functional role in aging of eye
Published - 02/04/20 - 09:00 AM | 3094 views | 85 85 comments | 24 24 recommendations | email to a friend | print

A lengthy-named gene called Elongation of Very Long Chain Fatty Acids Protein 2 or ELOVL2 is an established biomarker of age. In a new paper, published online Jan. 14, 2020 in the journal Aging Cell, researchers at the University of California San Diego School of Medicine say the gene appears to play a key role in age-associated functional and anatomical aging in vivo in mouse retinas, a finding that has direct relevance to age-related eye diseases. 

Specifically, the research team, led by senior author Dorota Skowronska-Krawczyk, Ph.D., assistant professor in the Viterbi Family Department of Ophthalmology at UC San Diego Shiley Eye Institute, found that an age-related decrease in ELOVL2 gene expression was associated with increased DNA methylation of its promoter. Methylation is a simple biochemical process in which groups of carbon and hydrogen atoms are transferred from one substance to another. In the case of DNA, methylation of regulatory regions negatively impacts the expression of the gene. 

When researchers reversed hypermethylation in vivo, they boosted EVOVL2 expression and rescued age-related decline in visual function in mice. “These findings indicate that ELOVL2 actively regulates aging in mouse retina, provides a molecular link between polyunsaturated fatty acids elongation and visual functions, and suggests novel therapeutic strategies for treatment of age-related eye diseases,” wrote the authors.

ELOVL2 is involved in production of long-chain omega-3 and omega-6 polyunsaturated fatty acids, which are used in several crucial biological functions, such as energy production, inflammation response and maintenance of cell membrane integrity. The gene is found in humans as well as mice. 

In particular, ELOVL2 regulates levels of docosahexaenoic acid or DHA, a polyunsaturated omega-3 fatty acid abundantly found in the brain and retina. DHA is associated with a number of beneficial effects. Notably, its presence in photoreceptors in eyes promotes healthy retinal function, protects against damage from bright light or oxidative stress and has been linked to improving a variety of vision conditions, from age-related macular (AMD) degeneration to diabetic eye disease and dry eyes. 

Skowronska-Krawczyk said the work demonstrated for the first time that a “methylation clock” gene had a functional role in the aging of an organ. In this case, the eye. DNA methylation is used throughout the human body, essentially turning biological switches on and off to maximize efficient operation. It has key regulatory roles in the body’s cardiovascular, neurological, reproductive and detoxification systems. 

In recent years, there has been much work and progress in identifying possible biomarkers that predict the biological age (not chronological) of individuals. Such biomarkers would be useful in identifying risk and status of age-related diseases. ELOVL2 is among the genes attracting greatest interest.  

“I have been asked whether I think ELOVL2 is the aging gene,” said Skowronska-Krawczyk. “After thinking about it, it is not unreasonable to think that lower ELOVL2 expression might be at the basis for many age-related conditions. Future work in our lab will address that question.” 

For the full study, visit https://onlinelibrary.wiley.com/doi/full/10.1111/acel.13100

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carla houston
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4 Hours Ago
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Mornacy
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15 Hours Ago
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Jackwanger
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18 Hours Ago


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19 Hours Ago
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Amy Kendral
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19 Hours Ago
Am testifying of the miraculous work of a great traditional doctor called  Dr Razor, I have been suffering from Hsv 2 for the past 4 years, but today I am happy that am completely cured from it with the herbal medicine made by  Dr Razor the great healer, I was browsing the Internet searching for help when I came across a testimony shared by one miss kendral on how  Dr Razor cured her from Hsv 2 virus. I quickly contacted him to get the cure and today i am now free from the Virus, Reach out to doctor razor herbs to get yours today Email : drrazorherbalhome@gmail.com Whatsapp or call him on  2349065420442
mofana fistos
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21 Hours Ago
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March 29, 2020
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March 28, 2020
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March 28, 2020
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bellorayr457
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March 28, 2020
I am BIANCA AQUINO from United States LAKEWOOD NEW JERSEY, I was having herpes 2 on my private part. I have had them for about 2 and a half years. I am so scared that my friends are going to laugh at me, if they should find out that I have herpes on my private part and due to the virus my boyfriend broke up with me. I have been to Doctors 9 times to get it treated. They all came back negative. I have also been using Tee Tree Oil and Wartner (I freeze them at home) and they seem to be keeping the smaller herpes small but they can't seem to treat the larger ones. They don't get any Bigger, but then they didn’t shrink as much. They get smaller a little part at a time. At least they are getting smaller! As soon as I see a new herpes appearing, then I treat it. At the moment I have been using Tee Tree twice a week and then using Wartner every 2 weeks. I was wondering if there was any other information about how to get rid of it. Sometimes it get sweet when Scratching it most times! I want to get rid of it so badly! Until i stubbed into DR. ekiadola Daily post on remedy for herpes diseases has posted by Sarah lifted from Dr.ekiadola daily post as advise to Mathew and George about the great herbal doctor how he has helped them get rid of these infectious diseases, and how this great herbal doctor called DR. ekiadola healed them; So that was when i switch for natural remedy to see if there could be any help by herbal remedy. That how i was cured. contact him on his email. ekiadolaherbalhome@gmail.com or whatsapp: 17784004580

jessica allen
|
March 27, 2020
I am so happy, i never believe i will be this happy again in life, I was working as an air-hoster ( cabby crew ) for 3years but early this year, i loose my job because of this deadly disease called Herpes virus (HSV), I never felt sick or have any symptom, till all workers were ask to bring their doctors report, that was how i got tested and i found out that am HSV positive that make me loose my job, because it was consider as an STD and is incurable disease, i was so depress was thinking of committing suicide, till i explain to a friend of mine, who always said to me a problem share is a problem solved, that was how she directed me to Dr Aba, that was how i contacted him and get the medication from this doctor and i got cured for real, I just went back to my work and they also carry out the test to be real sure and i was negative. Please contact this doctor if you are herpes positive or any STD diseases his email is: dr.abaherbalhome@gmail.com or you can call or whatsApp his mobile number on 2348107155060   
Jason Joy
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March 27, 2020
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lucy hale
|
March 27, 2020
I want to say a very thanks to Dr Isiramen, I have been cure from this terrible disease (Herpes) for over nine months now and I tried to share my testimony about how I was cure to people and they always told me that it not a permanent cure but I decide to go to a check up again and I discovered that I was still negative so Dr Isiramen is a very great man and he most different from other doctors because he did take me as his child and he never fail me and also he always keep his words he is the best doctor in African and I pray to God so that he can keep him alive email him if you need his help too via drisiramenherbalhome05@gmail.com or whatapps or call him on 2348054753640.
Adam Laura
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March 27, 2020
I am so happy to share this grate testimony of mine to everyone out here on how i was cured of my HIV, I have be living with HIV for over 5 years now and it has be a big problem to me. One day i came across a woman testimony on forum saying she get cured of her HIV with the help of Dr Teshe herbal remedy and advice anyone to contact the great man i email the doctor when he told me that he will help me cure my HIV with his herbal medicine i doubted it will not work but when he send me the medicine i started using it for 21 days week just as he told me then i discover that I was cured of it after taking the herbal medicine am here to tell you that is also having the same sickness you don't have to think about the cure because Dr Teshe has the cure kindly contact him so you can be cured too through his email drtashe@gmail.com. You can also call or whatsapp him on 234815472883 you are indeed a great man.
TYRONE DAVID
|
March 27, 2020
I want to thank Dr Ovie for the help he has rendered to me by getting Rid

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11 Hepatitis B…
Rebecca Holis
|
March 26, 2020
Hello everyone, I was infected with the herpes virus and I got cured of the herpes virus few months ago after i contacted Dr NICOLAS. I saw a post on the internet after i have seek healing for several years from different doctors in California. I sent the Doctor a request for help, just a few email i followed his instruction and he sent me the medication after i paid him. Now i am negative and i referred him to all my friend who had this same sickness and they have gotten their cure too. You can contact him via his email: drnicolasherbelhome@gmail.com

Call/WhatsApp: 2348158577976
wanda davis
|
March 26, 2020
Its a great pleasure for me to write this testimony about how i got my Genital Herpes cured a month ago. i have been reading so many comments of some people who were cured from various diseases by Dr Aza but i never believed them. I was hurt and depressed so I was too curious and wanted to try DR. Aza then i contacted him through his email, he assured me 100% that he will heal me, i pleaded with him to help me out. My experience with him was great, he healed me just as he promised. he sent me his medication and ask me to go for a medical check up after two weeks of usage. i agreed with him i took this medication and went for a check up, to my greatest surprise my result was negative, i am really happy that i am cured and healthy again. I have waited for 3weeks to be very sure i was completely healed before writing this testimony. I did another blood test one week ago and it was still Herpes negative. so i guess its time i recommend anyone going through the same way. reach him through his email address: drazaherbalcenter@gmail.com  OR call, add him on Whatsapp  1(315) 795 1518   
joyce lucky
|
March 26, 2020
I have been suffering from (HERPES SIMPLEX VIRUS) disease for the past one years and had constant pain, especially in my knees. During the first year,I had faith in God that i would be healed someday.This disease started circulating all over my body and i have been taking treatment from my doctor, few weeks ago i came on search on the internet if i could get any information concerning the prevention of this disease, on my search i saw a testimony of someone who has been healed from (HERPES SIMPLEX VIRUS) by this Man Dr patrick and she also gave the email address: dr.patrickherbalhome@gmail.com of this man and advise we should contact him for any sickness that he would be of help, so i wrote to Dr. patrick telling him about my (HERPES Virus) he told me not to worry that i was going to be cured!! hmm i never believed it,, well after all the procedures and remedy given to me by this man few weeks later i started experiencing changes all over me as the doctor assured me that i have cured,after some time i went to my doctor to confirmed if i have be finally healed behold it was TRUE, So friends my advise is if you have such sickness or any other at all you can email:: dr.patrickherbalhome@mail.com or whatsApp his number on 2348055367947      
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