Studies suggest that the synthetic ghrelin analog Hexarelin may promote growth hormone synthesis. The potential for Hexarelin to enhance lean mass via stimulating growth hormone synthesis has piqued the research community’s interest in this substance for organism composition analysis.
Hexarelin peptide has suggested promise in improving organism composition, but recent studies have suggested that it may exert neuroprotective and cardioprotective potential as well.
In the 1980s, a group of researchers from Tulane Medical School set out to design a growth hormone secretagogue (GHS) that would not lead to the unintended rise of sex hormones, insulin, or glucagon. They succeeded with Hexarelin. In their study, the researchers from Tulane suggested that Hexarelin may have had a longer-lasting effect on pituitary growth hormone stimulation than similar bigger peptides. Additionally, they speculated that rats given Hexarelin seemed to have gained weight and that desensitization at the receptor site was not an issue.
Properties unconnected to growth hormone secretion are beginning to surface due to scientists’ ongoing investigation of Hexarelin peptides.
Recent research on Hexarelin’s potential neuroprotective impacts has suggested that the hexapeptide may enhance neurogenesis in the hippocampus and lower inflammation in the brain, protecting cells from injury and death.
Scientists speculate that it is also intriguing that the peptide may contribute to the mitigation and possibly the prevention of heart attacks. Research has indicated that it may potentially improve cardiac output in cases of bypass surgery, increase cardiac output during ischemia episodes, and make cardiac muscle contractions more efficient.
Hexarelin Peptide Overview
Investigations purport that Hexarelin’s high growth hormone-stimulating potential may be its primary attraction, notwithstanding its wide range of possible impacts.
Organisms produce less growth hormone over time. There is a lot of interest in finding the best way to restore growth hormone levels using chemicals like Hexarelin. Growth hormone is involved in many functions, including making collagen, repairing muscles, maintaining bone density, and regulating the distribution and storage of fat cells. Here are three common justifications for the current Hexarelin research agenda.
Hexarelin Peptide and Pain
Findings imply that after an accident or strenuous physical activity, Hexarelin may help the organism heal muscles, tendons, and bones by secreting growth hormone. When the organism can recover from injuries quickly, it may exert harder physical activities for longer without suffering from the same baseline of strain.
There has also been a connection drawn between sleep cycles and tissue repair. Insomnia may have numerous causes, including decreased circulating growth hormone. Scientists speculate that deeper, more rejuvenating sleep, brought about by Hexarelin’s influence on growth hormone release, may be impactful foundationally in the organism’s composition.
Hexarelin Peptide and Fat
Several factors contribute to obesity, but insulin resistance is a big one. Nutrition & Diabetes published research in 2017 that evaluated the insulin sensitivity of two groups of female research models of obesity compared to that of a control group of non-obese models. Insulin sensitivity was the same in the weight-maintenance group as in the control group; however, insulin resistance was a predictable result in the weight-regain group of models.
Research has indicated that Hexarelin may improve metabolic rate and composition by increasing insulin sensitivity, decreasing fat, increasing lean mass, and decreasing blood triglycerides. Thus, it may enhance efficient food partitioning.
Hexarelin Peptide and the Heart
Research in heart conditions have traditionally lauded the exposure of small amounts of ghrelin to aid in the healing process after cardiac operations and adverse cardiac occurrences. Though ghrelin is a naturally occurring peptide, its effects are fleeting because it degrades quickly.
Studies suggest that compared to ghrelin, the synthesized hexapeptide Hexarelin may have more practical cardiac impacts, a longer half-life, and higher potency. Chronic heart failure cases may improve long-term cardiac performance, atherosclerosis may be reversed, and cardiac fibrosis and hypertrophy may decrease when Hexarelin is present.
Hexarelin Peptide Potential
Many successful studies have been conducted on Hexarelin, all of which are accessible for examination. Here, we review a few of the most important investigations.
Hexarelin peptide and muscle mass: Sirago et al. (2017) investigated whether growth hormone secretagogues might reduce cachexia, the severe loss of muscle mass that often occurs in cancer research models after chemotherapy.
Researchers used a chemotherapy substance to create the negative health indicators often seen in cancer test subjects in rats. Subsequently, the rats were assigned to one of three groups: one that got Hexarelin, one that did not, and a third that received JMV2894, an additional GHS.
In the control group, muscle atrophy and mitochondrial dysfunction were side effects of cisplatin, but GHS-treated animals suggested remarkable resistance to these effects. Research indicates this was because Hexarelin may have practical effects, including enhancing mitochondrial function, decreasing inflammatory processes, and controlling cell turnover to keep muscle mass functional.
Investigations purport that in addition to promoting growth hormone secretion, Hexarelin may enhance fat metabolism via its activity at the CD36 scavenger receptor, making it an effective tool for weight loss.
Researchers from Canada wanted to know more about Hexarelin’s fat-burning potential, so they treated adipocytes in rat white fat cell cultures. While increasing the expression of genes important for fat metabolism and increasing ATP-related energy generation in associated genes, Hexarelin appeared to dramatically lower triglyceride buildup in the treated cells via its action at CD36.
Findings imply that the Hexarelin action on lipolysis may have potential for weight reduction research, as white fat cells store most fat. Because it may upregulate ATP synthesis, Hexarelin has been hypothesized to increase fat-burning and metabolic rate.
Hexarelin peptide and brain protection: Neuroblastoma cells are the hallmark of the neurodegenerative illness amyotrophic lateral sclerosis (ALS). Motor control loss, paralysis, and death are the end outcomes of amyotrophic lateral sclerosis (ALS), which causes neuronal apoptosis in several parts of the neurological system. Even though there are only palliative therapies for amyotrophic lateral sclerosis (ALS) at the moment, scientists are determined to discover a cure for the condition.
In 2023, researchers used Hexarelin and JMV2894 on mutant cells to find a GHS-based approach for amyotrophic lateral sclerosis. To reduce cytotoxic inflammation and slow or reverse cell death, Meanti et al. (2023) included Hexarelin in the experiment due to the peptide’s speculated cytoprotective and anti-inflammatory characteristics.
According to the research, Hexarelin seemed to enhance mutant cell death and boost healthy cell survival. Although more research is necessary to fully comprehend the potential of growth hormone secretagogues as ALS approaches, these findings hold significant potential for the future usage of Hexarelin peptide.
Researchers interested in peptides for investigation purposes may click here to be redirected to the Biotech Peptides website, our recommended source of high-quality research compounds.
References
[i] Mosa, R. M., Zhang, Z., Shao, R., Deng, C., Chen, J., & Chen, C. (2015). Implications of Ghrelin and Hexarelin in Diabetes and Diabetes-Associated Heart Diseases. Endocrine, 49(2), 307–323. https://doi.org/10.1007/s12020-015-0531-z.
[ii] Bowers, C.,Momany, F., Reynolds, G.,Hong, A. (1984). On the in Vitro and in Vivo Activity of a New Synthetic Hexapeptide that Acts on the Pituitary to Specifically Release Growth Hormone. Endocrinology, 11(5), 1537–1545. https://doi.org/10.1210/endo-114-5-1537
[iii] Meanti, R., Licata, M., Rizzi, L., Bresciani, E., Molteni, L., Coco, S., Locatelli, V., Omeljaniuk, R. J., & Torsello, A. (2023). Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein. International Journal of Molecular Sciences, 24(2), 993. https://doi.org/10.3390/ijms24020993
[iv] Mao, Y., Tokudome, T., & Kishimoto, I. (2014). The Cardiovascular Action of Hexarelin. Journal of Geriatric Cardiology, 11(3), 253–258. https://doi.org/10.11909/j.issn.1671-5411.2014.03.007
[v] Rahim, A., O’Neill, P. A., & Shalet, S. M. (1998). Growth Hormone Status During Long-Term Hexarelin Therapy. The Journal of Clinical Endocrinology And Metabolism, 83(5), 1644–1649. https://doi.org/10.1210/jcem.83.5.4812.
[vi] Bartke A. (2019). Growth Hormone and Aging: Updated Review. The World Journal of Men’s Health, 37(1), 19–30. https://doi.org/10.5534/wjmh.180018
[vii] Doessing, S., Heinemeier, K. M., Holm, L., Mackey, A. L., Schjerling, P., Rennie, M., Smith, K., Reitelseder, S., Kappelgaard, A. M., Rasmussen, M. H., Flyvbjerg, A., & Kjaer, M. (2010). Growth Hormone Stimulates the Collagen Synthesis in Human Tendon and Skeletal Muscle Without Affecting Myofibrillar Protein Synthesis. The Journal of Physiology, 588(2), 341–351. https://doi.org/10.1113/jphysiol.2009.179325.
[viii] Kopchick, J. J., Berryman, D. E., Puri, V., Lee, K. Y., & Jorgensen, J. O. L. (2020). The Effects of Growth Hormone on Adipose Tissue: Old Observations, New Mechanisms. Nature Reviews. Endocrinology, 16(3), 135–146. https://doi.org/10.1038/s41574-019-0280-9
[ix] Kraemer, W. J., Ratamess, N. A., & Nindl, B. C. (2017). Recovery Responses of Testosterone, Growth Hormone, and IGF-1 After Resistance Exercise. Journal of Applied Physiology, 122(3), 549–558. https://doi.org/10.1152/japplphysiol.00599.2016.
[x] Vyazovskiy V. V. (2015). Sleep, Recovery, And Metaregulation: Explaining the Benefits of Sleep. Nature And Science of Sleep, 7, 171–184. https://doi.org/10.2147/NSS.S54036
[xi] Sirago, G., Conte, E., Fracasso, F., Cormio, A., Fehrentz, J. A., Martinez, J., Musicco, C., Camerino, G. M., Fonzino, A., Rizzi, L., Torsello, A., Lezza, A. M. S., Liantonio, A., Cantatore, P., & Pesce, V. (2017). Growth Hormone Secretagogues Hexarelin and JMV2894 Protect Skeletal Muscle from Mitochondrial Damages in a Rat Model of Cisplatin-Induced Cachexia. Scientific Reports, 7(1), 13017. https://doi.org/10.1038/s41598-017-13504-y
